Abstract
Hypoxia-inducible factor-1alpha (HIF-1alpha) is an intrinsic marker of tumor hypoxia. It has been considered that the hypoxic status reduces radiosensitivity, but the role of HIF-1alpha in advanced cervical carcinoma is still unclear. The objective of this study was to clarify the impact of HIF-1alpha, human papillomavirus (HPV), and other molecular factors, such as p53, bax, bcl-2, and their correlations on the outcome of patients with Stage IIIB cervical carcinoma in radiation therapy. We analyzed 38 patients with FIGO Stage IIIB squamous cell carcinoma of the cervix treated with radiation therapy alone. All patients received the combination therapy of external beam irradiation and low-dose-rate intracavity brachytherapy. The tumor expressions of HIF-1alpha, p53, bax, and bcl-2 were examined by immunohistochemical staining of the pretreatment paraffin embedded specimens. HPV infection was also detected by polymerase chain reaction. The effects of these parameters on clinical outcomes were analyzed by univariate analysis. Of 38 patients, high expression of HIF-1alpha, p53, bax, and bcl-2 were seen in 17 (45%), 22 (58%), 15 (39%), and 15 (39%) patients, respectively, and 28 patients (74%) showed positive infection with HPV. The...Continue Reading
References
Oct 29, 1992·Nature·D ShweikiE Keshet
Jan 1, 1992·British Journal of Cancer·M B ParliamentL I Wiebe
Dec 1, 1992·Molecular and Cellular Biology·G L Semenza, G L Wang
Nov 22, 1991·Science·H zur Hausen
Jul 5, 1991·Science·M HollsteinC C Harris
Apr 6, 1990·Science·B A WernessP M Howley
May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·R A GatenbyG J Broder
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Jun 7, 1995·Journal of the National Cancer Institute·F X BoschK V Shah
Jan 1, 1995·Radiology·N MitsuhashiH Niibe
Jul 30, 1994·International Journal of Radiation Oncology, Biology, Physics·N MitsuhashiH Niibe
Nov 5, 1993·Cell·M ScheffnerP M Howley
Mar 1, 1996·British Journal of Cancer·E SilesJ M Ruiz de Almodóvar
Dec 1, 1995·Investigative Radiology·M S ShinK J Ho
Oct 1, 1996·The American Journal of Physiology·B H JiangH H Marti
Dec 20, 1996·The Journal of Biological Chemistry·G L SemenzaA Giallongo
Apr 4, 1997·Cell·K Guillemin, M A Krasnow
Sep 5, 1997·The Journal of Biological Chemistry·S Salceda, J Caro
May 9, 1998·The Journal of Biological Chemistry·S M WoodP J Ratcliffe
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·L E HuangH F Bunn
Aug 11, 1998·Nature·P CarmelietE Keshet
Sep 22, 1998·British Journal of Cancer·K SundførE K Rofstad
Oct 23, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A W FylesR P Hill
Feb 26, 1999·The Journal of Biological Chemistry·P J KallioL Poellinger
Dec 28, 1999·Annual Review of Cell and Developmental Biology·G L Semenza
Jan 12, 2000·Archives of Disease in Childhood·D Hall
Feb 9, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T H KnockeR Pötter
Feb 9, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D M BrizelM W Dewhirst
Mar 29, 2000·British Journal of Cancer·M T SheridanR D Hunter
Jun 24, 2000·International Journal of Radiation Biology·E K Rofstad
Aug 6, 2000·British Journal of Cancer·E K RofstadC G Tropé
Jan 10, 2001·Cancer·H IshikawaH Niibe
Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·H SakuraiH Niibe
Jul 4, 2002·International Journal of Radiation Oncology, Biology, Physics·Hans Kristian HauglandDavid W Hedley
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Michael I KoukourakisAdrian L Harris
Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Jun-Ichi SaitohTakashi Nakano
Dec 20, 2002·The Oncologist·Louis B HarrisonDaniel Shasha
Citations
Apr 19, 2007·Cancer Metastasis Reviews·Peter Vaupel, Arnulf Mayer
Sep 13, 2008·Cancer Metastasis Reviews·Nicolas MagnéChristine Haie-Meder
Jun 20, 2012·Oncogene·Y ZhuH Harada
Jun 19, 2007·Antioxidants & Redox Signaling·Eui Jung MoonMark W Dewhirst
Mar 20, 2013·BioMed Research International·Michio YoshimuraMasahiro Hiraoka
Dec 4, 2012·International Journal of Molecular Sciences·Chan Joo YeomHiroshi Harada
Jul 30, 2009·International Journal of Radiation Biology·Marjaana LuukkaaHeikki Minn
Jun 24, 2008·Cancer Investigation·Valeska B GuzmanMaria Gerbase-Delima
Feb 2, 2012·Acta Oncologica·Christine EllingsenEinar K Rofstad
Oct 28, 2009·International Journal of Radiation Oncology, Biology, Physics·Yoko HarimaSatoshi Sawada
Jun 30, 2006·Cancer Science·Jiro FujimotoTeruhiko Tamaya
May 21, 2015·PloS One·Yue JinYu Wang
Feb 5, 2013·Annals of Diagnostic Pathology·Yanxiang ChengCuilan Li
Nov 26, 2008·International Journal of Radiation Oncology, Biology, Physics·Priyamal SilvaCatharine M L West
Sep 19, 2006·International Journal of Radiation Oncology, Biology, Physics·Hitoshi IshikawaHirohiko Tsujii
May 9, 2006·Gynecologic Oncology·Gabriella FerrandinaGiovanni Scambia
Jan 1, 2011·Cancers·Chan Joo YeomHiroshi Harada
May 25, 2011·Journal of Gynecologic Oncology·Min Kyu KimByoung-Gie Kim
Jun 19, 2018·International Journal of Radiation Biology·Michael I Koukourakis, Alexandra Giatromanolaki
Jul 1, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Miaoling HuangZhongqiu Lin
Apr 9, 2008·BJU International·Rupal S BhattGlenn J Bubley
Jan 25, 2020·Journal of Radiation Research·Keiichi TanakaHideyuki Sakurai
Mar 30, 2017·Frontiers in Immunology·Erik WennerbergSandra Demaria
Feb 23, 2010·Journal of Radiation Research·Takashi NakanoTakeo Takahashi
Mar 6, 2008·The Journal of Medical Investigation : JMI·Takashi KawanakaHiromu Nishitani
Nov 8, 2017·Scientific Reports·Kanako NakamuraHiroki Sasaki
Feb 16, 2019·Frontiers in Immunology·Laurel B DarraghSana D Karam
Sep 19, 2020·BMC Cancer·Tingting YaoZhongqiu Lin
Sep 29, 2011·Journal of Radiation Research·Hiroshi Harada
Sep 2, 2018·Clinical & Experimental Metastasis·Joaquín AraosBoyan K Garvalov
Nov 23, 2011·Journal of Radiation Research·Mariko ShioyaTakashi Nakano
Jan 5, 2019·Cancer Metastasis Reviews·Oliver Thews, Anne Riemann
Nov 6, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O V KurmyshkinaT O Volkova
Dec 30, 2016·Physics in Medicine and Biology·Emely LindblomIuliana Toma-Dasu
May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xudong TangAnh D Le
Jun 18, 2021·Experimental & Molecular Medicine·Tatsuya SuwaHiroshi Harada
Jul 16, 2010·Critical Reviews in Oncology/hematology·Laura M S SeeberPaul J van Diest