PMID: 6983113Sep 1, 1982Paper

Expression of Ia-like antigen in lymphatic leukaemias and non-hodgkin lymphomas in correlation with other surface markers

Scandinavian Journal of Haematology
L BergmannG Zerth

Abstract

Ia-like antigen, surface Ig, E-rosettes, mouse red blood cell rosettes and further surface markers were investigated in 88 specimens from 69 patients with various lymphocytic leukaemias and non-Hodgkin lymphomas. Ia-like antigen was detectable in all cases of sIg+ leukaemias and lymphomas. E-Ia+sIg-leukaemias, especially CLL and lymphomas were interpreted as B-cell neoplasias, which either did not produce sIg or expressed it in undetectable amounts. E+Ia+sIg+ malignant lymphocytes represented a B-cell population with antibody activity of sIg to SRBC. In the present series 9.5% of all B-cell leukaemias and lymphomas demonstrated this phenotype. Whereas ALL may possess Ia-like antigen, the vast majority of mature T-cell lymphomas are lacking it. In the present series 2 T-cell lymphomas expressed Ia-like antigen and did not contain TdT (E+Ia+sIg-TdT-). These lymphomas are probably derived from a stimulated T-cell clone synthesizing Ia-like antigen.

References

Nov 1, 1978·The Journal of Experimental Medicine·R L EvansS F Schlossman
Jul 1, 1979·British Journal of Cancer·J A HabeshawR L Brearley
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S F SchlossmanJ L Strominger
Jun 1, 1976·British Journal of Haematology·D CatovskyD A Galton
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari
Jun 1, 1976·Scandinavian Journal of Immunology·M Jondal
Jun 1, 1976·Scandinavian Journal of Immunology·H B Dickler
Jul 1, 1972·The Journal of Experimental Medicine·H B Dickler, H G Kunkel

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Citations

Jan 1, 1984·Cancer Immunology, Immunotherapy : CII·L BergmannW Kelker
Jul 1, 1984·Hematological Oncology·E AncelinF Huguet-Rigal
Feb 1, 1985·Scandinavian Journal of Haematology·L BergmannK C Weber
Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·A Porwit-KsiazekP Biberfeld

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