Expression of idiotypic antibodies-1 and -2 and breastfeeding in relation to antibody levels against Haemophilus influenzae type B in children

Scandinavian Journal of Immunology
S A SilfverdalP Olcén

Abstract

The aim of the study was to determine the concentrations of serum antibodies against Haemophilus influenzae type b in preschool children in relation to the distribution of idiotypic antibodies 1 and 2 (Id-1 and Id-2) and the exposure to breastfeeding in infancy. Sera were obtained from 74 control children recruited in an earlier case-control study before the introduction of general Hib vaccination. Duration of breastfeeding was monitored, and prevalence of noninvasive infections was registered. Concentrations of IgG1 and IgG2 anti-Hib, as well as of total Id-1 and Id-2, were determined in ELISA. The expression of Id-1 antibodies increased with age in contrast to the Id-2 antibodies that were found only in children up to 24 months of age. Expression of Id-1 antibodies was positively correlated with higher anti-Hib levels of both the IgG1 and IgG2 isotype. Children expressing Id-2 antibodies showed higher IgG2 anti-Hib concentrations than those who did not have Id-2 (P = 0.001). The concentrations of neither Id-1 nor Id-2 antibodies were related to the duration of breastfeeding. Duration of breastfeeding was related to increased anti-Hib IgG2 in healthy children above 18 months of age. These study shows that the expression of idi...Continue Reading

References

Oct 10, 1985·Journal of Immunological Methods·A SuttonR Schneerson
Jan 1, 1996·Scandinavian Journal of Infectious Diseases·O GarpenholtP Olcén
Sep 1, 1996·Clinical and Experimental Immunology·M UlanovaL A Hanson
Jan 19, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·L A Hanson
Jul 1, 1996·Journal of Mammary Gland Biology and Neoplasia·A S GoldmanF C Schmalstieg
Sep 28, 2002·The Pediatric Infectious Disease Journal·Sven-Arne SilfverdalPer Olcen

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Citations

Jul 15, 2009·Acta Paediatrica·Josè G Dòrea
Dec 17, 2008·Scandinavian Journal of Infectious Diseases·Lars A Hanson, Sven Arne Silfverdal

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