Expression of IL-13Ralpha2 in liver cancer cells and its effect on targeted therapy of liver cancer.

Journal of Cancer Research and Clinical Oncology
Lingling HouTao Hong

Abstract

Liver cancer is the third leading cause of cancer-related deaths globally. The number of liver cancers diagnosed in the world is increasing at an alarming rate. It is of great significance to find the new targets of the tumor cells and specific medicine. This research investigated the expression of interleukin-13 receptor alpha2 (IL-13Ralpha2) in different liver cancer cell lines and liver cancer tissues, and assessed the cytotoxin DT389-hIL13-13E13K (IL-13 and diphtheria toxin fusion protein) targeted killing effect on liver cancer cells. Based on study above, we further analyzed the function of IL-13Ralpha2 on the targeted liver cancer therapy. The results will provide a novel strategy and an alternative way for liver cancer therapy. The expression of IL-13Ralpha2 in different liver cancer cell lines and tissues were analyzed by RT-PCR and immunohistochemistry. Cytotoxicity assay of DT389-hIL13-13E13K was performed in eight different concentrations in liver cancer cell lines in vitro. At the same time, siRNA-mediated knockdown was introduced to assess the role of IL-13Ralpha2 in liver cancer therapy. Two out of four tested liver cancer cell lines and 27 out of 33 (81.82%) liver tissues expressed the IL-13Ralpha2. The fusion p...Continue Reading

References

Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mitomu KioiRaj K Puri
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Mar 7, 2006·Lipids in Health and Disease·Jingting JiangNing Xu
Jul 25, 2006·Critical Reviews in Oncology/hematology·Alejandro FornerJordi Bruix
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takeshi ShimamuraRaj K Puri
Dec 10, 2008·International Journal of Cancer. Journal International Du Cancer·Mitomu KioiRaj K Puri

❮ Previous
Next ❯

Citations

Sep 15, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming TuWeiming Zheng
Jan 24, 2017·Journal of Ethnopharmacology·Xiangrong ChenNa Guo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.