Expression of IL-33 in chronic lesional skin of canine atopic dermatitis

Veterinary Dermatology
Ryota AsahinaSadatoshi Maeda

Abstract

In humans, interleukin (IL)-33 plays a critical role in the enhancement of allergic skin inflammation. However, it currently remains unclear whether IL-33 is involved in the pathogenesis of canine atopic dermatitis (cAD). To examine the expression of IL-33 in chronic lesional skin of cAD. Eight dogs with spontaneous cAD and five healthy dogs were used. The transcription of il-33 in chronic lesional skin of cAD was quantified by quantitative reverse transcription PCR. The expression of IL-33 was evaluated immunohistochemically using an anti-human IL-33 monoclonal antibody with cross-reactivity to canine IL-33. The transcription levels of il-33 in chronic lesional skin of cAD were significantly higher than those in normal skin of healthy dogs. Keratinocytes were a major cellular source of IL-33 production in chronic lesional skin of cAD. The results indicate that IL-33 is involved in chronic lesional skin of cAD.

References

May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T J NuttallP B Hill
Jun 29, 2002·Veterinary Immunology and Immunopathology·Sadatoshi MaedaHajime Tsujimoto
Jan 5, 2012·The Journal of Biological Chemistry·Rahul KakkarRichard T Lee
Feb 27, 2014·Journal of the American Academy of Dermatology·Risa Tamagawa-MineokaNorito Katoh
Mar 5, 2015·The Journal of Investigative Dermatology·Olav SundnesDenis Khnykin
Jun 28, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hong-Yang DuWei Liu

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Citations

Apr 24, 2021·Veterinary Dermatology·Rosanna Marsella
Aug 12, 2021·Veterinary Dermatology·Tetsuro Kobayashi, Ichiro Imanishi

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