Abstract
A nitric oxide (NO) synthase (NOS) can be induced in both astrocytes and cerebral endothelial cells with a combination of interleukin-1 beta/interferon-gamma or lipopolysaccharide/interferon-gamma, respectively. Exogenous NO, either from the chemical donor spermine NONOate or from activated astrocytes, affected the expression of inducible NOS in cerebral endothelial cells. In cerebral endothelial cells pretreated with spermine NONOate the induction of NOS was reduced, as revealed by mRNA expression and nitrite accumulation. Cytokine-treated astrocytes generating NO and placed in close proximity to endothelial cells decreased the expression of NOS induced by cytokines in endothelial cells. In addition, it was apparent that cytokine-activated astrocytes released a factor(s) that initiated transcriptional induction of NOS in cerebral endothelium. This suggests that astrocytes activated by cytokines in vivo could influence expression of inducible NOS in cells of the adjacent microvasculature.
Citations
Aug 1, 1997·Journal of Neurosurgery·T MathiesenB Andersson
Dec 1, 2004·Journal of Neurochemistry·M ChisariM A Sortino
Jul 12, 2008·IUBMB Life·Paola StefanelliRodolfo Ippoliti
Jun 1, 1999·Journal of Neurosurgery·D C WidenkaH J Steiger
Aug 5, 1998·International Journal of Clinical & Laboratory Research·P MartellettiM Giacovazzo
Oct 8, 1997·Neurosurgery·Y SuzukiJ Yoshida
Jan 1, 1997·Journal of Neural Transmission·H W ClementW Wesemann
May 16, 2000·Journal of Biomedical Science·C A Fairbanks, G L Wilcox
May 29, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Geraldine PragerHarald Engler
Feb 16, 1999·Brain Pathology·K J SmithP A Felts
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·J G ArenbergW S Quirk
Feb 28, 2007·Toxicologic Pathology·Lilian Calderón-GarcidueñasWilliam Reed
Feb 21, 2003·Glia·Laurence DescampsGérard Torpier
Jun 18, 2002·Journal of Neurochemistry·Despina ConstantinSean Murphy
Jan 7, 1998·Glia·R A Shafer, S Murphy
Aug 29, 2000·Cephalalgia : an International Journal of Headache·G StirparoP Martelletti
Feb 13, 2002·Journal of Neurosurgery·Emmanuel CunyJacques Demotes-Mainard
Feb 17, 2007·American Journal of Therapeutics·Joseph Prandota
Dec 1, 1996·Journal of Neuroimmunology·A H CrossT P Misko
Feb 20, 1998·Neuroscience Letters·B SeidelG Wolf