Expression of insulin-like growth factor binding protein-2 (IGFBP-2) gene in negative and positive human cytomegalovirus glioblastoma multiforme tissues.

Medical Oncology
Narges AhaniAbbas Nikravesh

Abstract

Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults and has but few treatments. The median survival of glioblastoma patients is 12 months. The (possible) relationship between human cytomegalovirus (HCMV) infection and cancer has been investigated for decades. Detection of viral DNA, mRNA and/or antigens in tumor tissues suggests that HCMV infection has a role to play in the etiology of several human malignancies. HCMV gene products can promote the various signaling pathways critical to tumor growth, including platelet derived growth factor receptor, phosphatidyl inositol 3-kinases (PI3K/AKT), signal transducer and activator of transcription 3 and glycogen synthase kinase 3 beta that are involved in apoptosis, angiogenesis, invasion and immune evasion. Insulin-like growth factor binding protein 2 (IGFBP2) is a biomarker of the PI3K/AKT pathway so we decided to evaluate the expression of this gene in 3 groups: HCMV-negative GBM tissues, HCMV-positive GBM tissues and non-tumor tissues. The presence of HCMV was assessed according to our previous article. HCMV was present in %75 of glioblastoma tissues. Then RNA was extracted, cDNA was synthesized, and real-time...Continue Reading

References

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Citations

Apr 30, 2014·Frontiers in Endocrinology·Andreas HoeflichJulia Brenmoehl
Apr 18, 2015·PLoS Computational Biology·Ka Wai LinAmina A Qutub
Aug 31, 2018·Journal of Cellular Biochemistry·Narges AhaniMajid Alipour Eskandani
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaofeng YaoLun Zhang
Sep 14, 2019·Endocrine Regulations·Dmytro O MinchenkoOleksandr H Minchenko
Oct 21, 2017·Oncotarget·Feng ChenChun-Xiang Xiang

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