Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes

Endocrinology
D LandauD LeRoith

Abstract

Recent studies have shown that the renal synthesis of insulin-like growth factor binding proteins (IGFBPs) is altered in insulin-deficient diabetes mellitus, suggesting that these changes may be implicated in the alterations in renal function and morphology that accompany diabetes. To investigate the time course and the precise cellular distribution of changes in IGFBP expression, we used quantitative in situ hybridization to analyze renal IGF-I and IGFBP-1 to -5 messenger RNA (mRNA) localization and levels from 2 days to 6 months after the onset of streptozotocin-induced diabetes. There was an immediate sharp decline in IGF-I mRNA levels in the outer medulla that persisted for up to 3 months and a much smaller reduction in IGF-I mRNA levels in the medullary thick ascending limbs (MTALs). In nondiabetic animals, IGFBP-1 mRNA is most abundant in the MTALs. Immediately after the induction of diabetes, however, there was a greater than 2-fold increase in cortical IGFBP-1 mRNA and a 75% decrease in IGFBP-1 mRNA in MTALs. These changes persisted for up to 6 months in the diabetic animals. In contrast, IGFBP-5 mRNA levels were increased in the outer medulla and decreased in the cortex of diabetic kidneys. No significant changes in re...Continue Reading

Citations

Jan 30, 2010·Experimental Diabetes Research·Laura A MaileDavid R Clemmons
Feb 16, 2005·Reviews in Endocrine & Metabolic Disorders·Sowmya K Surya, Ariel L Barkan
Mar 1, 1997·Kidney International·F C FervenzaR Rabkin
Jun 8, 2006·The Journal of Veterinary Medical Science·Ho Jae Han, Soo Hyun Park
Feb 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anne K Berfield, Christine K Abrass
Jan 29, 2000·Clinical Endocrinology·J A Janssen, S W Lamberts
Apr 19, 2005·Treatments in Endocrinology·Vidya Mohamed-Ali, Jonathan Pinkney
Jan 1, 2008·Expert Review of Endocrinology & Metabolism·Daniel Landau, Yael Segev
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·M ShinadaL A Bach
Feb 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L A BachM E Cooper
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·D Le Roith, A A Butler
Jan 22, 1998·The American Journal of Physiology·C K AbrassD L Andress
Nov 30, 2000·American Journal of Physiology. Renal Physiology·A De La PuenteA M Pascual-Leone
Dec 14, 1999·Journal of Endocrinological Investigation·G PuglieseU Di Mario
Jan 28, 2005·Experimental Biology and Medicine·Vesna Cingel-RistićAllan Flyvbjerg
Dec 5, 1998·The American Journal of Physiology·M J HorneyS A Rosenzweig
Apr 8, 1998·The American Journal of Physiology·Z SymonI Raz
Mar 13, 2003·Kidney International·Gabriella GrudenGiancarlo Viberti

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