Expression of insulin-like growth factor-I in cows at different stages of lactation and in late lactation cows treated with somatotropin

Journal of Dairy Science
B K SharmaN K Ames

Abstract

Relative amounts of IGF-I mRNA were measured in livers of Holstein cows at different stages of lactation (6 early, 6 mid, 6 late lactation, 6 dry) and 6 late lactation cows treated with bST for 1 wk. Milk yield was greater for early lactation cows than for mid and late lactation controls. All cows except those in early lactation were in positive energy balance. Serum IGF-I increased as lactation progressed and was greatest during the dry period. Liver IGF-I mRNA was less in cows in early than in late lactation but greater in lactating than in dry cows. Treatment with bST increased milk yield and concentrations of serum IGF-I, hepatic IGF-I mRNA, and serum IGF-binding protein-3, decreased concentration of serum IGF-binding protein-2, and did not alter abundance of mammary IGF-I mRNA. These parallel changes in serum IGF-I and hepatic IGF-I mRNA suggest that exogenous bST increases IGF-I synthesis in liver of cows during late lactation and that IGF-I synthesis is depressed during early lactation when cows are in negative energy balance. We conclude that IGF-I may play an endocrine role in mediating galactopoietic effects of exogenous bST during late lactation. However, the role of IGF-I during early lactation remains unclear.

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Citations

Nov 5, 2011·Biological Chemistry·Lorenzo CastigliegoAlessandra Guidi
Jun 14, 2005·Domestic Animal Endocrinology·F VangroenwegheC Burvenich
Jul 31, 2002·Journal of Dairy Science·B K WhitlockH A Tucker
Nov 7, 2006·Journal of Animal Physiology and Animal Nutrition·P H M RodriguesC S Lucci
Nov 9, 2001·Journal of Dairy Science·N FernandezF Adriaens
Jan 28, 2012·Cell Biochemistry and Function·Jarinthorn TeerapornpuntakitNarattaphol Charoenphandhu
Jan 25, 2011·Journal of Dairy Science·A HayirliHélène Petit
Jun 24, 2003·Journal of Animal Science·P E KendallG E Dahl
Apr 14, 2006·Journal of Animal Science·M L SchlegelS R Rust
Dec 2, 2006·Domestic Animal Endocrinology·Mark A FenwickD Claire Wathes

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