PMID: 9657575Jul 10, 1998Paper

Expression of insulin-like growth factors and their binding proteins by bronchoalveolar cells from children with and without interstitial lung disease

The European Respiratory Journal
K ChadelatA Clement

Abstract

The involvement of the insulin-like growth factor (IGF) system in lung growth and repair following injury is sustained by a number of studies. Based on this knowledge, the aim of the present work was to document the expression of the IGFs and their binding proteins by alveolar cells obtained by bronchoalveolar lavage (BAL). Two groups were investigated: a control group of five children and a group of 11 children referred to the department for exploration of interstitial lung disease (ILD). Components of the IGF system studied included IGF-I, IGF-II and IGF-binding proteins (IGFBP). Expression of these factors was analysed at the level of messenger ribonucleic acid (mRNA) (by semi-quantitative reverse transcription polymerase chain reaction techniques), and of protein for the IGFBPs. In addition, expression of two major cytokines associated with the inflammatory process, tumour necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta), was also documented. In children without parenchymal disease, the growth factor expressed was IGF-I, in association with the presence of mRNA for IGFBP-2 in all cases. In children with ILD, expression of IGF-I was observed in nine patients and of IGF-II in three patients, an...Continue Reading

Citations

Feb 17, 2001·Pediatric Pulmonology·T Nicolai
Aug 16, 2001·Respiration Physiology·H YamamotoE Shimizu
May 3, 2002·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hiroyuki YamamotoEiji Shimizu
Jun 1, 1999·Current Opinion in Pediatrics·M S Howenstine, H Eigen
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·J M CharpinD Israël-Biet
Feb 28, 2002·American Journal of Respiratory Cell and Molecular Biology·Ian B Copland, Martin Post
May 11, 2010·Pathology, Research and Practice·Wenjing Ruan, Kejing Ying
Aug 19, 2014·The Tohoku Journal of Experimental Medicine·Nao HirotaSakae Homma
May 25, 2016·BMC Pulmonary Medicine·J GuiotR Louis
Jan 17, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elena MilanesiLuisella Bocchio-Chiavetto
Sep 18, 2004·Pediatric Pulmonology·Leland L FanClaire Langston
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Margaret K Winkler, John L Fowlkes
May 27, 2021·Scientific Reports·Julien GuiotRenaud Louis

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