PMID: 11326914May 1, 2001Paper

Expression of integrin beta 3 and intracellular adhesion molecule in endometrium and endometriotic tissue

Zhonghua fu chan ke za zhi
J WuY Liu

Abstract

To study the relationship between integrin beta 3, intracellular adhesion molecule (ICAM) and endometriosis. The expression of integrin beta 3 and ICAM protein were determined in 3 batches by immunoblotting method in 15 endometrium and 15 endometriotic tissues of patients with endometriosis and 30 endometrium from non-endometriosis subjects during the same menstrual phase. The results were scanned and semi-quantified, and then analysed by F test and t test. The results from 3 measurements showed the same trend. Endometrium from patients with endometriosis expressed significantly fewer integrin beta 3 and ICAM protein than those without endometriosis. On the other hand, the expression of integrin beta 3 in endometriotic tissue was significantly lower while the ICAM expression was significantly higher than those in controls. In patients with endometriosis, integrin beta 3 and ICAM expression changed significantly from eutopic to ectopic endometrium which may be related to the development of endometriosis and infertility.

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.