Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significance.

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
D J PapachristouAthanasios G Papavassiliou

Abstract

Integrin-linked kinase (ILK) and its binding partners alpha-parvin, beta-parvin, Mig-2 and Migfilin are important components of the cell-matrix adhesions implicated in cell motility, growth, survival and ultimately carcinogenesis. Herein, we investigated immunohistochemically the expression of these molecules in cartilaginous neoplasms and explored their involvement in chondrosarcoma pathobiology and behaviour. Our analyses revealed that ILK, alpha-parvin, beta-parvin and Mig-2 are expressed in the majority of chondrosarcomas but in a small proportion of enchondromas, implying that these proteins might have a role in the development and progression of chondrogenic neoplasms. Moreover, our findings highlight the possibilities that ILK might serve as biological marker that could accurately predict a high-grade tumour and that Mig-2 may function as a promising prognostic indicator of high-risk patients.

References

Nov 6, 2001·The Journal of Biological Chemistry·Sotiris N Nikolopoulos, Christopher E Turner
Apr 3, 2003·EMBO Reports·Carsten GrashoffReinhard Fässler
May 14, 2003·The EMBO Journal·Cord Brakebusch, Reinhard Fässler
Jul 30, 2003·Cancer Metastasis Reviews·Sujata Persad, Shoukat Dedhar
Jan 30, 2004·Cancer Cell·Clara TanShoukat Dedhar
Jan 27, 2005·Journal of Cell Science·Vasiliki GkretsiChuanyue Wu
Nov 30, 2005·Cellular and Molecular Life Sciences : CMLS·J L Sepulveda, C Wu
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Kyle R LegateReinhard Fässler
Jun 22, 2006·Clinical Orthopaedics and Related Research·Elke R AhlmannThomas Learch
Dec 30, 2006·Biochemical and Biophysical Research Communications·Vasiliki GkretsiGeorge K Michalopoulos
Apr 20, 2007·Human Pathology·Mayumi OkamuraYoshiaki Ishigatsubo
May 22, 2007·The Journal of Biological Chemistry·Xiaohua ShiChuanyue Wu
Jun 19, 2007·Molecular Cancer Therapeutics·Ronald P C WongGang Li
Jul 17, 2007·Clinical Orthopaedics and Related Research·Taninnit LeerapunFranklin H Sim

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Citations

Jan 11, 2018·BMC Musculoskeletal Disorders·Dominik MalcherczykJürgen R J Paletta
May 15, 2018·Analytical Cellular Pathology (Amsterdam)·Georgios TsiniasVasiliki Bravou
Aug 14, 2009·International Journal of Cancer. Journal International Du Cancer·Jun LiMengfeng Li
Dec 3, 2016·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Konstantinos KaramesinisChristina Piperi
May 22, 2018·Frontiers in Oncology·Vasiliki Gkretsi, Triantafyllos Stylianopoulos
Nov 10, 2009·International Journal of Radiation Biology·Iris EkeNils Cordes
Apr 26, 2017·Frontiers in Pharmacology·Francesco R EvolaGiuseppe Sessa
Dec 21, 2018·Expert Review of Clinical Immunology·Concetta SchianoClaudio Napoli
Jun 21, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Seung Hwan RheeHan-Soo Kim
May 18, 2016·Experimental Biology and Medicine·Christos AdamopoulosAthanasios G Papavassiliou
Nov 6, 2018·Cancer Cell International·Sheng LiuZengwu Shao
Aug 3, 2011·Radiologic Clinics of North America·Sue C Kaste

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