Expression of interleukin 1-beta, transforming growth factor beta-1, and vascular endothelial growth factor in soft tissue over the implant before uncovering

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Stefan Schultze-MosgauMichael Thorwarth

Abstract

Overexpression of inflammatory cytokines interleukin 1-beta (IL-1beta), transforming growth factor beta-1 (TGF-beta1), and vascular endothelial growth factor (VEGF) may cause healing impairment following implant insertion, jeopardizing success especially in patients previously irradiated. Limited data is available regarding expression pattern of inflammatory cytokines in peri-implant soft tissue caused by the surgical intervention itself. This study examined 21 patients receiving dental implants. Biopsies of peri-implant tissue were harvested at re-entry 4 months after initial surgery. Eight patients underwent probing of untreated mucosa. Three groups were created (group 1: regular peri-implant mucosa; group 2: patients with irradiated peri-implant mucosa, radiation treatment due to oral squamous cell cancer; group 3: control). Immunohistochemical staining was performed for TGFss1, IL-1ss, and VEGF. Following the placement of dental implants (group 1 vs group 3) a significant increase (P > .05) in TGF-beta1, IL-1beta, and VEGF expression in the peri-implant mucosa was demonstrated. No alteration of this distinct pattern was found for previously irradiated tissue (group 1 vs. group 2). The study highlights the fundamental involv...Continue Reading

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Citations

May 2, 2014·The Journal of Oral Implantology·Flaviana Soares RochaDarceny Zanetta-Barbosa
Apr 27, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Cornelia Katharina MuellerStefan Schultze-Mosgau
Sep 12, 2008·Clinical Implant Dentistry and Related Research·Danilo Alessio Di StefanoVittoria Perrotti
Nov 6, 2008·Clinical Oral Implants Research·G Huynh-BaG E Salvi
Sep 30, 2010·Archives of Oral Biology·G A ScardinaP Messina
Mar 5, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Qun LeiZhiyu Cai
Jun 11, 2011·Annals of Plastic Surgery·Cornelia Katharina MuellerStefan Schultze-Mosgau
Apr 10, 2010·International Journal of Immunopathology and Pharmacology·G SchieranoA M Cuffini
May 4, 2021·Journal of Indian Prosthodontic Society·Kaushal Kishor AgrawalSaumyendra Vikram Singh
Dec 2, 2021·Journal of Biomedical Materials Research. Part a·Yosuke AsamiYasutomo Yajima

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