Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer

Annals of Surgical Oncology
Satheesha HanavadiWen G Jiang

Abstract

Recent experimental evidence has shown a potential role of interleukin (IL)-11 and its receptor in breast cancer development and progression. However, there is little clinical information to support this hypothesis. We examined the expression of IL-11 and its receptor in primary breast cancer tissue samples and correlated their level of expression with the clinical outcome. Primary breast cancer samples (n=109) and matched background tissue obtained from patients in the cohort (n=33) were processed for frozen section and RNA extraction. Frozen sections from matched tissues were immunostained with IL-11 and IL-11 receptor antibodies. Staining intensity was analyzed by computer image analysis. RNA was reverse-transcribed and quantified before analysis by quantitative polymerase chain reaction. Results were expressed as the number of transcripts (standardized by beta-actin). The data were compared with the clinical outcome of the disease. The intensity of staining for both IL-11 and the IL-11 receptor was distinctly high in tumor samples (P<.01). The transcript level of IL-11 was significantly higher in node-positive tumor samples compared with node-negative samples (P=.02). Tumors with a poor prognostic index and poor histologica...Continue Reading

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Citations

Jan 28, 2014·Nature Methods·James ZouJennifer Listgarten
Feb 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chiang-Ching HuangElizabeth J Perlman
Jun 15, 2011·The Oncologist·Zuo-Lin XiangXiao-Dong Zhu
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Jun 18, 2010·Reproductive Biology and Endocrinology : RB&E·Joanne YapEvdokia Dimitriadis

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