PMID: 9180138May 29, 1997Paper

Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma

International Journal of Cancer. Journal International Du Cancer
P L LolliniP Nanni

Abstract

Interleukin 15 (IL-15) is a recently discovered cytokine that stimulates lymphocyte proliferation and migration via a trimeric receptor sharing the beta and gamma signal transducing chains with the IL-2 receptor. IL-15 is typically produced by normal cells that do not release IL-2, but little information is currently available on human tumors. To assess whether human musculo-skeletal sarcomas produce IL-15, we analyzed surgical specimens and cell lines obtained from rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma. IL-15 mRNA was present in 9/9 surgical specimens (3 Ewing's sarcomas, 5 osteosarcomas and 1 rhabdomyosarcoma). The analysis of a panel of cell lines (7 derived from Ewing's sarcoma, 12 from osteosarcoma and 5 from rhabdomyosarcoma) showed that all rhabdomyosarcoma and osteosarcoma cell lines expressed IL-15 mRNA at levels ranging from low to high, while Ewing's sarcoma cells contained little or no IL-15 message. ELISA assays showed IL-15 release in a subset of rhabdomyosarcomas and osteosarcomas, but not in Ewing's sarcoma. The highest production of IL-15, in the picogram/ml range, was found in rhabdomyosarcoma cell lines RH30 and RD.

References

Jul 1, 1994·Immunology Today·C H JuneC B Thompson
Aug 1, 1995·Endocrinology·L S QuinnK H Grabstein
Feb 10, 1995·Genomics·D M AndersonS W Morris
Mar 1, 1995·The Journal of Experimental Medicine·P C Wilkinson, F Y Liew

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Citations

Nov 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·Lebris S QuinnJosép M Argilés
Oct 8, 1999·Leukemia & Lymphoma·Y Yamada, S Kamihira
Jul 19, 2013·Mediators of Inflammation·Silja Raschke, Jürgen Eckel
Jan 3, 2001·Blood·T A Fehniger, M A Caligiuri
Apr 18, 2009·Molecular Cancer Therapeutics·Patrizia NanniPier-Luigi Lollini

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