Expression of interleukin 2 and the interleukin 2 receptor in aging rats

Cellular Immunology
N J HolbrookE L Schneider

Abstract

Lymphocytes of aged animals exhibit a marked decrease in proliferative capacity in response to mitogen stimulation when compared to those of younger animals. In humans and mice the decreased proliferation is due at least in part (i) to the inability of lymphocytes to synthesize sufficient interleukin 2 (IL-2) and (ii) to decreased expression of IL-2 receptors (IL-2R) on the surface of aged lymphocytes. We compared proliferative abilities, IL-2 production, and IL-2R expression in splenocyte cultures of 4- to 5- and 22- to 24-month-old Fischer 344 rats stimulated with either concanavalin A (Con A) or A23187 and phorbol myristate acetate (PMA). Proliferation was significantly decreased in aged lymphocytes (30-50%) with both treatment protocols. However, unlike mice and humans we observed no difference in IL-2 activity, IL-2 mRNA levels, or IL-2R cell surface expression of lymphocytes from young and aged rats stimulated with either Con A or A23187 and PMA. These results indicate that factors other than decreased expression of IL-2 and IL-2R are responsible for the diminished proliferative capacity of aged rat lymphocytes following mitogen stimulation.

Citations

Aug 1, 1991·Journal of Cellular Biochemistry·M V HobbsD J Noonan
Dec 21, 2004·Biogerontology·Mónica De la FuenteJesus A F-Tresguerres
Oct 1, 1998·Age·E D Bernstein, D M Murasko
Dec 31, 1991·Mechanisms of Ageing and Development·R G GoyaJ Meites
Aug 29, 1996·Mechanisms of Ageing and Development·M A Pahlavani, A Richardson
Jun 7, 2005·Cellular Immunology·Paul Hasler, Moncef Zouali
Aug 16, 2005·The Journal of Nutritional Biochemistry·Catherine J FieldTapan Basu
Jul 16, 1999·Mechanisms of Ageing and Development·B Chakravarti, G N Abraham
Mar 9, 2000·Mechanisms of Ageing and Development·M LiF Sierra
Dec 26, 1992·Annals of the New York Academy of Sciences·G GrassoN Fabris
Jun 19, 2001·Aging : Clinical and Experimental Research·P MascarucciM A Lane
Nov 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T L NagelM P Schweizer
Jun 1, 1994·Aging : Clinical and Experimental Research·R PaganelliI J Ansotegui

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