PMID: 7523315Oct 15, 1994Paper

Expression of interleukin 2 receptors on human carcinoma cell lines and tumor growth inhibition by interleukin 2

International Journal of Cancer. Journal International Du Cancer
S YasumuraTheresa L Whiteside

Abstract

We have previously shown that human squamous cell carcinomas (SCC) express the interleukin 2 receptor (IL2R)-alpha and -beta chains, and that the ligand, IL2, directly inhibits growth of the tumor in vitro and in vivo in the tumor xenograft-nude mice model. We now show that the alpha and beta chains of IL2R are expressed on a variety of human carcinoma cell lines and on normal human keratinocytes in early-stage cultures. While all carcinoma cells in a population expressed IL2R-alpha and -beta proteins, in keratinocytes obtained from different normal donors, variable proportions of cells were positive, as measured by flow cytometry. The carcinoma lines and 2/5 keratinocyte lines studied were also found to contain transcripts for the IL2R-gamma chain detectable by combined reverse transcription-PCR (RT-PCR) and hybridization with the specific cDNA probe. Incubation of the gastric (HR) or renal cell carcinoma (RCC) cell lines, but not of other IL2R+ carcinoma cell lines or normal keratinocytes, in the presence of IL2 resulted in dose-dependent inhibition of tumor cell growth. Monoclonal antibodies (MAbs) specific for IL2R-beta chain completely reversed this growth inhibitory effect of IL2. The ligand, IL2, also down-regulated surf...Continue Reading

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Citations

Dec 10, 2002·Biochemical and Biophysical Research Communications·Patricia H CasanaManuel J Arana
Jun 29, 2002·Veterinary Immunology and Immunopathology·A Gröne
Dec 1, 1996·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T YanoY Ichinose
Feb 27, 2008·Cancer Biotherapy & Radiopharmaceuticals·David LooseChristophe Van de Wiele
Aug 3, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michelle Holko, Bryan R G Williams
Oct 27, 2011·Melanoma Research·Emily Y JenElizabeth A Grimm
Jun 22, 2011·OncoTargets and Therapy·Michael AbernKalyan Latchamsetty
Oct 12, 2007·European Journal of Nuclear Medicine and Molecular Imaging·David LooseChristophe Van de Wiele
Jun 7, 2003·Scandinavian Journal of Immunology·V T BlokA Gorter
Mar 11, 2011·Journal of Biochemical and Molecular Toxicology·James V RogersJohn S Graham
Jun 14, 2016·Mediators of Inflammation·Arturo Valle-MendiolaIsabel Soto-Cruz
Apr 12, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A R KamerC Liebow
May 30, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T E ReichertT L Whiteside
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·S NagashimaT L Whiteside
Nov 11, 1999·British Journal of Cancer·T E ReichertT L Whiteside
Aug 19, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Olivier LesurTamas Füllöp
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V M CorrigallG S Panayi

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