PMID: 11897800Mar 19, 2002Paper

Expression of invariant chain (CD 74) and major histocompatibility complex (MHC) class II antigens in the human fetus

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Sunil BadveLennart Lögdberg

Abstract

During the initiation of an immune response, antigen-presenting cells employ MHC class II antigens as key molecules to present small peptides to CD4-positive lymphocytes. The invariant chain (Ii; CD74) plays a critical role in this process by influencing the expression and peptide loading of the MHC class II molecules. Therefore, coordinate expression of these molecules is believed to play an important role in antigen presentation. This study explores the expression of these molecules in fetal tissues. Formalin-fixed, paraffin-embedded multi-organ tissue blocks from aborted fetuses (age range 7-22 weeks) were immunostained for Ii/CD74 and MHC class II antigens using commercially available monoclonal antibodies for Ii/CD74 (LN2) and MHC class II antigens (LN3), respectively. Coordinate staining for Ii/CD74 and MHC class II antigens was seen in the skin, proximal renal tubules, tips of small intestinal mucosa, and cells of the reticuloendothelial system, including the spleen and thymus. Expression of Ii/CD74, but not of MHC class II antigens, was seen in pulmonary alveolar epithelium in all cases and in testicular Leydig cells (11 of 11 testes examined). The distribution and intensity of staining did not change significantly with...Continue Reading

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Citations

Sep 11, 2012·Cytokine & Growth Factor Reviews·M D Sanchez-NiñoA Ortiz
Jul 24, 2015·American Journal of Respiratory and Critical Care Medicine·Morane Le HiressChristophe Guignabert
Aug 6, 2010·Medicinal Research Reviews·Ibrahim Mustafa El-DeebSo Ha Lee
Feb 4, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mei SyafriadiTakashi Saku
Jan 7, 2011·Expert Opinion on Therapeutic Targets·Federica Borghese, Felix I L Clanchy
Apr 21, 2018·BMC Bioinformatics·Hoai Nam NguyenCharles Kervrann
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Xinwen WangXiaochun Bai
Nov 30, 2005·Veterinary Immunology and Immunopathology·Dalian ZhongJing Liu
Sep 10, 2008·Biochimica Et Biophysica Acta·Jaime AcquavivaAl Charest

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