Expression of iodine metabolism genes in human thyroid tissues: evidence for age and BRAFV600E mutation dependency

Clinical Endocrinology
Carla EspadinhaMaria João Bugalho

Abstract

Children present a higher susceptibility to developing thyroid cancer after radioiodine exposure and also a higher frequency of functional metastases than adults. To assess the mRNA expression of the sodium/iodide (Na(+)/I(-)) symporter (NIS), the Pendred syndrome gene (PDS), thyroperoxidase (TPO), thyroglobulin (Tg) and TSH receptor (TSH-R) in normal thyroid tissues (NTTs) and papillary thyroid carcinomas (PTCs) among different age groups. Analysis included 59 samples: 21 NTTs and 38 PTCs, of which 21 were the classic type (CPTC) and 17 the follicular variant (FVPTC). Patients were divided into three age groups: I (n = 16) 5-21 years, II (n = 13) 22-59 years, and III (n = 10) 60-91 years. The relative mRNA expression of the five target genes was determinate by quantitative reverse transcription polymerase chain reaction (QRT-PCR). Expression of all genes was significantly higher in NTTs than in PTCs, and it was not age dependent in the NTT group. Among PTCs, the mean expression of PDS, TPO and TSH-R was significantly lower in group II than in group I. PDS, TPO and Tg expression was significantly lower in classic PTCs than in FVPTCs. The difference was related to a higher frequency of the BRAF(V600E) mutation in the former grou...Continue Reading

References

Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·I Vollenweider, C Hedinger
Jan 1, 1981·World Journal of Surgery·J A BuckwalterC G Thomas
Sep 1, 1995·British Journal of Cancer·H R Harach, E D Williams
Jan 29, 1998·The New England Journal of Medicine·M J Schlumberger
Sep 16, 1999·The Journal of Clinical Endocrinology and Metabolism·V LazarM Schlumberger
Apr 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M D RingelR M Tuttle
Dec 19, 2001·Lancet·Y ShibataS Nagataki
Jun 12, 2002·Lancet·Luc A Michel, Julian E Donckier
Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Wellington Hung, Nicholas J Sarlis
Feb 18, 2003·Endocrine Reviews·Orsolya DohánNancy Carrasco
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Ludovic LacroixJean-Michel Bidart
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Efisio PuxedduFausto Santeusanio
May 29, 2004·International Journal of Epidemiology·Martin C MahoneyPhilip L McCarthy
Jun 10, 2004·Genes, Chromosomes & Cancer·Volkert B WreesmannBhuvanesh Singh
Apr 30, 2005·Cytopathology : Official Journal of the British Society for Clinical Cytology·R DominguesM J Bugalho
May 19, 2005·Journal of the National Cancer Institute·Elisabeth CardisDillwyn Williams
Jun 11, 2005·Endocrine-related Cancer·M Xing
Oct 13, 2005·The Journal of Clinical Endocrinology and Metabolism·P CastroM Sobrinho-Simões

❮ Previous
Next ❯

Citations

Feb 23, 2013·Nature Reviews. Cancer·Mingzhao Xing
Apr 7, 2012·Journal of Oncology·Carla EspadinhaMaria João Bugalho
Jul 30, 2011·Journal of Molecular Endocrinology·Dagmara RusinekBarbara Jarzab
Oct 27, 2009·Future Oncology·Paula Soares, Manuel Sobrinho-Simões
Nov 4, 2009·Molecular and Cellular Endocrinology·Mingzhao Xing
Apr 28, 2011·Clinical Endocrinology·Elaine C MorariLaura S Ward
Aug 27, 2015·Endocrine-related Cancer·Maria Isabel C Vieira CordioliJanete M Cerutti
Mar 30, 2016·International Journal of Endocrinology·Maria Isabel Cunha Vieira CordioliJanete Maria Cerutti
Nov 8, 2014·Experimental & Molecular Medicine·Yong Won ChoiTae Jun Park
Mar 30, 2019·Pediatric Blood & Cancer·Luiza SisdelliJanete Maria Cerutti
Sep 19, 2009·Expert Review of Anticancer Therapy·Paolo MiccoliMichele N Minuto
Sep 22, 2019·Genes·Vera A PaulsonDouglas S Hawkins
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Xiao Hong LiuC Andrew van Hasselt
Jul 8, 2016·World Journal of Surgery·Yi-Chiung HsuShih-Ping Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.