Expression of JC virus T-antigen in a patient with MS and glioblastoma multiforme

Neurology
L Del ValleK Khalili

Abstract

To investigate the presence of human polyomavirus JC virus genome and the expression of the viral oncoprotein T-antigen in neoplastic cells of a patient with MS and a glioblastoma multiforme. The postmortem examination of an immunocompetent patient with a neurologic disorder revealed the concurrence of MS plaques in the white matter of the brain and a glioblastoma multiforme in the region of the thalamus. PCR analysis of DNA from demyelinated plaques and the tumor area using primers derived from specific regions of the JC virus genome revealed the presence of viral DNA corresponding to the viral early and late genes. Further examination of the samples for the JC virus regulatory region identified the presence of sequences identical to JC virus Mad-4 and JC virus W1 viral isolates in the tumor and the demyelinated regions. Results from immunohistochemistry showed the detection of the viral early protein, T-antigen, and the cellular tumor suppressor protein, p53, in the nuclei of neoplastic cells. Interestingly, expression of T-antigen, but not p53, was observed in neurofilament-positive cells with neuronal morphology and in glial fibrillary acidic protein-positive astrocytes in the cortex juxtaposed to the MS plaques. Examinatio...Continue Reading

Citations

Jul 16, 2005·Virchows Archiv : an International Journal of Pathology·Ryouta HoriYasuo Takano
Apr 14, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Robert Saddawi-Konefka, John R Crawford
Dec 25, 2012·Emerging Infectious Diseases·Florante N Dela CruzPatricia A Pesavento
Nov 13, 2015·Neurosurgical Review·Tihomir EftimovElitsa Encheva
Oct 13, 2010·Journal of Neuroimmunology·Robert Weissert
Dec 14, 2011·Journal of Neuropathology and Experimental Neurology·Christian Wüthrich, Igor J Koralnik
Jun 10, 2009·Seminars in Cancer Biology·Melissa S Maginnis, Walter J Atwood
Jun 27, 2009·Annals of Neurology·Christian WüthrichIgor J Koralnik
Dec 26, 2003·Journal of Medical Virology·Byung-Hoon JeongYong-Sun Kim
Oct 13, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Martyn K White, Kamel Khalili
Jun 29, 2005·Brain Research. Brain Research Reviews·Martyn K WhiteKamel Khalili
Mar 20, 2015·Frontiers in Neurology·Domenico PlantoneTatiana Koudriavtseva
Aug 12, 2003·Oncogene·Umberto GalderisiAntonio Giordano
Aug 12, 2003·Oncogene·Kamel KhaliliJennifer Gordon
Sep 3, 2020·International Journal of Molecular Sciences·Nicholas AhyeHassen S Wollebo
May 2, 2012·Journal of Neuro-oncology·Adam KhalilB K Kleinschmidt-DeMasters
Apr 25, 2006·Multiple Sclerosis : Clinical and Laboratory Research·K Khalili, M K White
Nov 30, 2019·Pediatric Neurology·Grant A Dixon, Carlos A Pérez
Mar 13, 2021·Multiple Sclerosis and Related Disorders·Samir AlkabieGeorge J Hutton

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