PMID: 8952618Sep 1, 1996Paper

Expression of keratinocyte growth factor in periapical lesions

Journal of Dental Research
Z GaoIan Campbell Mackenzie

Abstract

The epithelial proliferation associated with inflammatory periapical lesions and with periapical cyst formation represents an interesting but poorly understood pathological change. Keratinocyte growth factor (KGF) is a recently identified growth factor that is produced by stromal fibroblasts and acts specifically to stimulate epithelial growth and differentiation. To investigate its possible role in the activation of the normally quiescent rests of Malassez, we examined the expression of KGF by in situ hybridization of sections of normal periodontal ligament (PDL) and of 12 periapical granulomas or cysts. Normal PDL and periapical granulomas with scant inflammatory infiltration showed few cells expressing message for KGF. However, KGF-expressing cells were found in the connective tissue stroma close to dense foci of inflammatory cells and to proliferating epithelial elements and cystic epithelial linings. Examination of tissues by the reverse-transcription polymerase chain reaction (RT-PCR) showed KGF expression in 4 specimens of periapical lesions but low or undetectable levels in normal PDL. These observations suggest that the induction of KGF expression in the stromal cells of periapical lesions may play an important role in...Continue Reading

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Citations

Jan 10, 2001·In Vitro Cellular & Developmental Biology. Animal·T YamanakaT Okamoto
Apr 25, 2013·Journal of Endodontics·David Keinan, Robert E Cohen
Nov 26, 2015·Journal of Endodontics·Lisiane BernardiPantelis Varvaki Rados
Jun 18, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P López JornetM Alcaraz Baños
Feb 7, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mehtap MuglaliMahmut Sumer
Apr 25, 2006·Journal of Endodontics·Ivan MoldauerSergio Kuttler
Jun 30, 2015·International Endodontic Journal·N AidaT Muramatsu
Jan 18, 2011·Journal of Endodontics·Eleni MeliouHippokratis Kiaris
Dec 3, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P N R Nair
Aug 9, 2001·Journal of Endodontics·R LeonardiS Travali
Mar 1, 2005·Journal of Periodontal Research·Min LiEdward E Putnins
Sep 7, 2007·Oral Microbiology and Immunology·M AndricL Todorovic
Feb 1, 2003·European Journal of Oral Sciences·Scott Thomas William McKeownChristopher Robert Irwin
Jul 9, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shun-Yao KoTsung-Yun Liu

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