Expression of Kit and Etv1 in restricted brain regions supports a brain-cell progenitor as an origin for cranial germinomas

Cancer Genetics
Chris Tan, Paul Scotting

Abstract

Mismigrating germ-cell progenitors have historically been accepted as the cell of origin for central nervous system (CNS) germinomas. However, an alternative hypothesis suggests that CNS germinomas arise from a brain-cell progenitor. Germinomas often acquire Kit signaling pathway mutations, and there is evidence for an oncogenic relationship between KIT and the ETV1 transcription factor. KIT appears to be necessary to stabilize ETV1, and ETV1 then activates oncogenesis-associated genes. ETV1 expression is not increased by KIT, so ETV1 already needs to be expressed in order for KIT to have an oncogenic function. Therefore, if brain-cell progenitors are the cell of origin for germinomas, those cells would already need to coexpress ETV1 and KIT. We examined Kit and Etv1 in situ hybridization data from the Allen Brain Atlas, for mouse brain tissue at various stages of development. Both Kit and Etv1 were expressed in the regions where germinomas most commonly arise, and in the medulla oblongata. All human cases of germinomas correlated to the regions where ETV1 and KIT are coexpressed. We therefore postulate that germinomas in the brain share a similar mechanism with other KIT-driven cancers, which supports the hypothesis that germi...Continue Reading

References

May 1, 1994·Neurologia Medico-chirurgica·K SugiyamaF Ikawa
Apr 1, 1993·Neurologia Medico-chirurgica·T TashiroH Abe
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·T E MerchantL E Kun
Jun 30, 2000·Surgical Neurology·H NakajimaH Kishi
Aug 23, 2001·Molecular Human Reproduction·L L RobinsonR A Anderson
Aug 16, 2002·Acta neurochirurgica·S KonnoK Fujii
Apr 27, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kyung-Sub MoonSam-Suk Kang
May 21, 2005·Nature Reviews. Cancer·Paul J ScottingGiorgio Perilongo
May 26, 2005·Neurologia Medico-chirurgica·Satoshi UtsukiKiyotaka Fujii
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Hiroyuki OginoMikio Mimura
Mar 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Sridurga Mithra PrabhuKate Lakoski Loveland
May 16, 2006·Pediatric Blood & Cancer·Andrea RossiPaolo Tortori-Donati
May 15, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Wolf MuellerAndreas von Deimling
Aug 21, 2007·International Journal of Andrology·J Wolter OosterhuisLeendert H J Looijenga
Jun 4, 2008·Cancer Research·Roger D PalmerUNKNOWN Children's Cancer and Leukaemia Group
Mar 14, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jiro AkimotoJo Haraoka
May 14, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Sreepoorna K UnniDeepa Bhartiya
Jul 24, 2010·Virchows Archiv : an International Journal of Pathology·Dakeun Lee, Yeon-Lim Suh
Jul 29, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yajie WangBaoqin Gao
Jul 31, 2010·Neurologia Medico-chirurgica·Hajime YonezawaKazunori Arita
Nov 4, 2010·Neurology India·R NeelimaV V Radhakrishnan
Oct 7, 2011·British Journal of Neurosurgery·Siyi WanggouQiaoyu Li
Dec 7, 2011·International Journal of Surgical Pathology·Shin-ichi NakatsukaTakuyu Taki
Feb 11, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Takashi ShutoNaoki Hasegawa
Aug 29, 2012·The Journal of Pathology·Chris Tan, Paul J Scotting
Jan 24, 2014·Acta Neuropathologica·Shintaro FukushimaUNKNOWN Intracranial Germ Cell Tumor Genome Analysis Consortium (iGCT Consortium)

❮ Previous
Next ❯

Citations

Oct 21, 2016·Pediatric Blood & Cancer·Ashley S PlantLindsay Frazier
Jan 21, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A S FerreiraE H C de Oliveira
Aug 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·José A GomezVictor J Dzau

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.