PMID: 9632562Jun 25, 1998Paper

Expression of Legionella pneumophila virulence traits in response to growth conditions

Infection and Immunity
B Byrne, M S Swanson

Abstract

In nature, Legionella pneumophila replicates exclusively as an intracellular parasite of amoebae, but it also persists in the environment as a free-living microbe. Studies of how this opportunistic pathogen recognizes and responds to distinct extracellular and intracellular environments identified a link between the growth phase and expression of traits previously correlated with virulence. When cultured in broth, only post-exponential-phase L. pneumophila was sodium sensitive, cytotoxic, osmotically resistant, competent to evade macrophage lysosomes, infectious, and motile. Likewise, the L. pneumophila phenotype changed during growth in macrophages. During the intracellular replication period, this bacterium was sodium resistant and lacked flagella; concomitant with macrophage lysis, L. pneumophila became sodium sensitive and flagellated. Expression of the virulent phenotype was a response to starvation, since exponential-phase L. pneumophila became cytotoxic, sodium sensitive, and motile after incubation in broth from stationary-phase cultures, except when it was supplemented with amino acids. Together, these data indicate that while nutrients are plentiful, intracellular L. pneumophila organisms are dedicated to replication;...Continue Reading

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Citations

Aug 14, 1999·Molecular Microbiology·B K Hammer, M S Swanson
Jun 10, 2000·Microbiology·S L CirilloJ D Cirillo
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K TatedaT J Standiford
Dec 19, 2000·Infection and Immunity·S L CirilloJ D Cirillo
Jul 23, 2003·Infection and Immunity·Purnima BandyopadhyayHoward M Steinman
Jun 10, 2004·Molecular Microbiology·Javier Pizarro-Cerdá, Karsten Tedin
Jul 24, 2004·Infection and Immunity·Purnima BandyopadhyayHoward M Steinman
May 13, 2005·Cellular Microbiology·Amal O Amer, Michele S Swanson
Aug 31, 2006·The Journal of Experimental Medicine·Vicki P Losick, Ralph R Isberg
Sep 18, 2007·Journal of Bacteriology·Gen-ichiro SanoKoichi Matsuo
Jan 28, 2009·Molecular Microbiology·Rachel L EdwardsMichele S Swanson
Oct 21, 2009·Infection and Immunity·Natalie N WhitfieldMichele S Swanson
Mar 31, 2010·Infection and Immunity·Rachel L EdwardsMichele S Swanson
Jun 25, 2010·Molecular Microbiology·Hans K CarlsonMichael A Marletta
Dec 7, 2011·Infection and Immunity·Yoshifumi KimizukaKeizo Yamaguchi
Jun 18, 2011·Science·M Ramona NeunuebelMatthias P Machner
Jan 31, 2014·Infection and Immunity·Maris V FonsecaMichele S Swanson
Aug 27, 2015·BMC Genomics·Laam LiSébastien P Faucher
Oct 29, 2019·Annual Review of Pathology·Sonia MondinoCarmen Buchrieser
Apr 23, 2002·Molecular Microbiology·Brian K HammerMichele S Swanson
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Maria Laura BoschiroliDavid O'Callaghan
Jun 22, 2002·FEMS Microbiology Letters·Hagen WielandBirgid Neumeister

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