Expression of leptin in colorectal adenocarcinoma showed significant different survival patterns associated with tumor size, lymphovascular invasion, distant metastasis, local recurrence, and relapse of disease in the western province of Saudi Arabia

Medicine
Jaudah Ahmed Al-MaghrabiMohamad Nidal Khabaz

Abstract

Leptin phenotype has been suggested to be a possible biomarker for the diagnosis and prognosis of different neoplasms. Nonetheless, there are conflicts among the outcomes found in several tumors, and little is proven concerning the correlation between the phenotype of leptin and its clinical significance in colorectal carcinomas. This study will describe the phenotype of leptin in colorectal adenocarcinomas, and investigate its correlation with clinicopathological factors.Two hundred and twenty eight tissue samples include 155 colorectal carcinomas, 40 adenomas, and 33 noncancerous cases were utilized in constructing tissue microarrays which have been used in the revealing of leptin expression using leptin monoclonal antibody and immunohistochemistry staining protocol.Immunoexpression of leptin was recognized in 145 (93.5%) of colorectal tumors and 56 (76.7%) cases of control group. Histotype was considerably associated with leptin phenotype (P = .000), there is up regulation in leptin expression in colorectal carcinoma cases. Significantly higher proportion of negative leptin immunostaining cases were observed in tumors which have size more than 5 cm (P = .045). Whereas, significant different survival patterns were observed in...Continue Reading

References

Nov 1, 1996·Diabetes·J F CaroR V Considine
Sep 2, 1998·Nature·A BadoM J Lewin
Sep 11, 1998·Science·M R Sierra-HonigmannJ R Flores-Riveros
Jun 30, 2000·Human Reproduction Update·R R GonzálezP Bischof
Jul 5, 2001·Gastroenterology·J C HardwickM P Peppelenbosch
Jan 11, 2007·The British Journal of Surgery·M R HodaK E Barrett
Sep 4, 2008·International Journal of Cancer. Journal International Du Cancer·Tamara Jaffe, Betty Schwartz
Sep 19, 2008·International Journal of Cancer. Journal International Du Cancer·Cecilia CarinoRuben R Gonzalez
Dec 3, 2009·Endocrine-related Cancer·Janina RatkeKerstin Lang
Jun 9, 2010·Archives of Pathology & Laboratory Medicine·Giacomo PuppaGiuseppe Pelosi
Feb 27, 2014·Biochemical and Biophysical Research Communications·Kang Nyeong LeeSeung Sam Paik
Apr 5, 2014·Oncology Reports·Kyung-Won YoonJong-Sun Rew
Apr 18, 2014·Nutrition and Cancer·Virginie DuboisFlorence Caldefie-Chezet
Mar 27, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xi ZhouZi Liu
Jan 28, 2016·Annals of Coloproctology·Woon Kyung JeongHye Soon Kim
Aug 16, 2017·Annals of Diagnostic Pathology·Jaudah Al-MaghrabiMohamad Nidal Khabaz
Oct 3, 2017·Annals of Diagnostic Pathology·Mohamad Nidal KhabazJaudah Al-Maghrabi

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Citations

Jul 1, 2020·BioMed Research International·Chunxiang LiZheng Jiang
Jul 3, 2021·Biomolecules·Carlos Jiménez-CorteganaVíctor Sánchez-Margalet

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