Expression of leucocyte chemoattractants by interstitial renal fibroblasts: up-regulation by drugs associated with interstitial fibrosis

Clinical and Experimental Immunology
S González-CuadradoJ Egido

Abstract

Interstitial inflammation is a strong predictor of long-term renal damage. The potential role of renal interstitial fibroblasts in recruitment of inflammatory leucocytes into the interstitium is unclear. We have thus studied the mRNA expression of several leucocyte chemotactic factors by rat renal interstitial fibroblasts and its modulation by cytokines. In addition, the effects of two unrelated drugs associated with the development of interstitial fibrosis, namely puromycin aminonucleoside (PAN) and cyclosporin A (CsA), were also studied. Rat renal interstitial fibroblasts showed constitutive mRNA expression for the chemokines monocyte chemoattractant protein 1 (MCP-1) and interferon-inducible protein 10 (IP-10). In addition, these cells also exhibited constitutive mRNA expression for cyclophilin B, an immunophilin recently found to have leucocyte chemoattractant properties. The inflammatory cytokine tumour necrosis factor-alpha up-regulated IP-10 and MCP-1 mRNA expression (10- and four-fold, respectively), but had no effect on cyclophilin B mRNA levels. IP-10 and MCP-1 produced about a four-fold increase in MCP-1 and cyclophilin B mRNA expression, but did not affect IP-10 mRNA. PAN caused an augmentation in IP-10, MCP-1 and c...Continue Reading

Citations

Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Fabrice AllainGeneviève Spik
Mar 13, 2003·Kidney International·Hans-Joachim AndersDetlef Schlöndorff
May 20, 2004·Kidney International·Ravi Raju TatapudiManikkam Suthanthiran
Jun 21, 2007·Kidney International·M J KoziolekF Strutz
Nov 2, 2002·Kidney International. Supplement·Marta Ruiz-OrtegaJesus Egido
Jan 25, 2011·Journal of Thrombosis and Haemostasis : JTH·A Enzerink, A Vaheri
Jan 31, 2013·Photochemistry and Photobiology·Alvaro C UceroAlberto Ortiz
Jun 29, 1999·The Journal of Laboratory and Clinical Medicine·Z L OuY Natori
Jul 16, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Keisuke IshizawaToshiaki Tamaki
Jul 29, 2003·Diabetes Care·Berthold AmannBernhard Angelkort
Jan 27, 2004·The American Journal of Pathology·Stephan SegererHermann-Josef Gröne
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·Tobias SilzleLeoni A Kunz-Schughart
Dec 4, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fariba PoostiJan-Luuk Hillebrands
Jul 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adeline MarcantFabrice Allain
Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Stephan SegererDetlef Schlöndorff

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