PMID: 15223819Jun 30, 2004Paper

Expression of leukocyte adhesion molecules in human subfoveal choroidal neovascular membranes treated with and without photodynamic therapy

Investigative Ophthalmology & Visual Science
Deborah C YehJorge G Arroyo

Abstract

The purposes of this study were to investigate the immunostaining of the leukocyte adhesion molecules intercellular adhesion molecule (ICAM)-1 and E-selectin in subfoveal choroidal neovascular membranes (CNVMs) surgically excised from patients with age-related macular degeneration (AMD) and to determine whether prior photodynamic therapy (PDT) alters their immunostaining. The localization of ICAM-1 and E-selectin in 10 subfoveal CNVMs was determined by immunohistochemistry. Membranes were also immunostained for CD31 to assess vascularity. Significantly higher numbers of CD31-staining vessels per unit membrane area were found in the peripheral regions of the membranes compared with the central regions (P = 0.05). ICAM-1 immunoreactivity in the CNVMs was found predominantly on RPE cells, but also on small vessels in the periphery. ICAM-1 staining was significantly more intense in the peripheral, more cellular areas of the membranes than in the central, more fibrotic regions (P = 0.04). ICAM-1 staining in the periphery of the CNVMs was greater than that in choroidal vessels and the RPE of the normal control eye. ICAM-1 immunostaining grade in peripheral regions of the CNVMs decreased with the increasing number of PDT treatments (P...Continue Reading

Citations

Sep 4, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Akira HirataHidenobu Tanihara
Sep 22, 2006·The British Journal of Ophthalmology·Olcay TatarSalvatore Grisanti
Jan 25, 2007·The British Journal of Ophthalmology·Jorge G Arroyo
Aug 28, 2010·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Mark E KleinmanJayakrishna Ambati
Apr 28, 2011·BMC Medical Genetics·Robert F MullinsJohn H Fingert
Jan 28, 2014·PloS One·Elliott H SohnRobert F Mullins
Jan 7, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kunbei LaiJian Ge
Jun 9, 2005·American Journal of Ophthalmology·Ronald KleinMichael Y Tsai
Jul 16, 2008·Progress in Retinal and Eye Research·Salvatore Grisanti, Olcay Tatar
Aug 5, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Norihiro NagaiSusumu Ishida
Aug 4, 2006·Journal français d'ophtalmologie·L MalvitteG Lizard

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