Expression of leukocyte immunoglobulin-like receptor subfamily B expression on immune cells in hepatocellular carcinoma.

Molecular Immunology
Jing FanYongxiang Yi

Abstract

Leukocyte immunoglobulin-like receptor subfamily B (LILRB) is a group of inhibitory receptors involved in innate immune mainly expressed on lymphoid and myelomonocytic cells. LILRB is proposed to serve as immune checkpoint like PD-1 and CTLA-4 for tumor treatment. We recently reported that the expression of LILRB2 in CD1c+ mDC from tumor tissue might suppress immune for HCC patients. However, the expression of all the LILRB family on other immune cells in peripheral blood and tumor microenvironment of HCC patients has not been systematically studied. The expression of LILRB family (LILRB1, LILRB2, LILRB3, LILRB4 and LILRB5) on immune cells, including granulocytes, NK cells, NKT cells, monocyte subsets, TAMs, B cells, γδ T cells, CD4+ T cells, CD8+ T cells and MDSC subsets, was analyzed by flow cytometry in the peripheral blood of 20 HCC patients and 20 healthy donors as well as in the tumor and tumor free tissues of 10 HCC patients. LILRB1, LILRB2 and LILRB3 in granulocytes from peripheral blood were expressed increased in HCC patients compared with healthy donors. The expression of LILRB5 in NK cells and NKT cells from HCC blood were higher compared with healthy donors` blood. CD14+CD16+ monocyte subsets in blood of HCC patient...Continue Reading

References

Jul 6, 2000·Immunobiology·D S AllanV M Braud
Oct 6, 2000·Science·J V Ravetch, L L Lanier
Apr 4, 2002·Trends in Immunology·Annalise M MartinFrank T Christiansen
Jan 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicodemus TedlaJonathan P Arm
Oct 12, 2004·Biochemical and Biophysical Research Communications·Joan SayósMiguel López-Botet
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emilie VieyAnne Caignard
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Virginie Prod'hommePeter Tomasec
Apr 29, 2008·American Journal of Human Genetics·Kouyuki HirayasuToshio Yabe
Sep 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shota EndoToshiyuki Takai
Jul 16, 2010·Blood·Loems Ziegler-HeitbrockManfred B Lutz
Jul 31, 2013·Immunobiology·Maria Rosaria GaldieroSébastien Jaillon
Oct 8, 2013·Journal of Translational Medicine·Maddalena MarchesiGiuseppe V Masucci
Oct 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jeremy BaudhuinBenoit Favier
Jan 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abderrahim NajiNathalie Rouas-Freiss
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Dec 23, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yunching ChenDan G Duda
Apr 29, 2015·Nature Cell Biology·Xunlei KangCheng Cheng Zhang
Jun 13, 2015·Nature Reviews. Immunology·Ping Shen, Simon Fillatreau
Aug 22, 2015·American Journal of Reproductive Immunology : AJRI·Snezana DjurisicThomas Vauvert F Hviid
Oct 24, 2015·Science·Richard N HannaCatherine C Hedrick
Jun 24, 2017·Cancer Immunology, Immunotherapy : CII·William van der TouwShu-Hsia Chen
Dec 11, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Rui WanAn-Qi Cheng
Jan 31, 2018·Nature Immunology·Marc RingelhanMathias Heikenwalder
Jan 31, 2018·Nature Reviews. Immunology·Koji Taniguchi, Michael Karin
Mar 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ester LozanoCarlos Fernández de Larrea
Apr 13, 2018·Biochimica Et Biophysica Acta. Reviews on Cancer·Aiqin GaoGuangyong Peng
Jun 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aeryon KimXin Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.