Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer

PloS One
Yoon Yang JungJa Seung Koo

Abstract

The tumor biology of metastatic breast cancers differ according to the metastatic sites, and the features of cancer metabolism may also be different. The aim of this study is to investigate the expression of lipid metabolism-related proteins in metastatic breast cancer according to metastatic site and discuss the clinical significance thereof. Immunohistochemical staining for lipid metabolism-related proteins [fatty acid synthase (FASN), hormone-sensitive lipase (HSL), carnitine palmitoyltransferase IA (CPT-1A), acyl-CoA oxidase 1 (ACOX1), fatty acid binding protein 4 (FABP4,) and perilipin 1 (PLIN1)] was performed using a tissue microarray of 149 cases of metastatic breast cancer (bone metastasis = 39, brain metastasis = 37, liver metastasis = 21, and lung metastasis = 52). The expression levels of ACOX1 (p = 0.009) and FASN (p = 0.007) varied significantly according to metastatic site, with the highest expression in brain metastasis and the lowest expression in liver metastasis. ACOX1 positivity (p = 0.005) and FASN positivity (p = 0.003) correlated with HER-2 positivity. The expression of FASN was significantly higher in HER-2 type breast cancer, and lower in luminal A and TNBC type breast cancer (p<0.001). Among lipid metab...Continue Reading

References

Sep 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·J J EganC Londos
Apr 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D C AllredL Eudey
Sep 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T KuukasjärviJ Isola
Nov 15, 1997·Cancer·E C WoodhouseL A Liotta
Dec 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M ColleoniC M Rudenstam
Oct 5, 2002·Journal of Lipid Research·Fredric B Kraemer, Wen-Jun Shen
Dec 13, 2002·American Journal of Clinical Oncology·Hüseyin Abali, Ismail Celik
Feb 24, 1956·Science·O WARBURG
Sep 3, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·A J EvansK L Cheung
Jun 24, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L AlbigesS Delaloge
Sep 30, 2005·The American Journal of Pathology·Robert J WeilPatricia S Steeg
Apr 4, 2006·Toxicology and Applied Pharmacology·Sara Rodríguez-EnríquezRafael Moreno-Sánchez
Sep 26, 2006·Pathology Oncology Research : POR·Tamás LôrinczMiklós Szendrôi
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Feb 17, 2007·The FEBS Journal·Rafael Moreno-SánchezEmma Saavedra
Jun 2, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jochen GaedckeHans H Kreipe
Nov 21, 2008·American Journal of Clinical Pathology·Carmen Gomez-FernandezMehrdad Nadji
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Nov 18, 2010·Breast Cancer Research : BCR·Quanri JinFrancisco J Esteva
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Feb 22, 2012·Recent Patents on Anti-cancer Drug Discovery·Di-Xian LuoEdmund Maser
Jul 11, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P KarlssonUNKNOWN International Breast Cancer Study Group
Aug 8, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peter Schönfeld, Georg Reiser

❮ Previous
Next ❯

Citations

Sep 19, 2017·Expert Opinion on Therapeutic Targets·Javier A Menendez, Ruth Lupu
Feb 5, 2016·Journal of Cellular Physiology·William B KinlawNancy B Kuemmerle
Aug 10, 2019·International Journal of Molecular Sciences·Naiara Santana-CodinaAngels Sierra
Aug 31, 2017·Cancer & Metabolism·Nathan J LanningCarrie R Graveel
Nov 1, 2017·Hormone Molecular Biology and Clinical Investigation·Amitabha Ray
Jul 14, 2019·The Journal of Pharmacology and Experimental Therapeutics·Leslie E LupienPaul W Baures
Jul 13, 2018·Cancer Communications·Ching-Ying Kuo, David K Ann
Oct 20, 2020·Frontiers of Medicine·Deyu ZhangQinong Ye

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
light microscopy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.