Expression of lipid-protein gene PLP2 in Liaoning cashmere goat

Animal Biotechnology
Mei JinJing'ai Piao

Abstract

The relationship between PLP2 gene and cashmere fiber quality of Liaoning cashmere goat was investigated. The sheep fibroblast cells were treated with exogenous cytokines and melatonin, independently, and RNA interference, RT-PCR and in situ hybridization were utilized for investigating the PLP2 gene regulation mechanism underlying the Liaoning cashmere growth. The results showed that the expression of PLP2 gene in the prosperous and degenerative stage is higher than that of the primary follicle, indicating that the PLP2 gene promotes the secondary follicle, wherein the gene is expressed only in the inner root sheath, suggesting its correlation to hair loss. The results of RT-PCR showed that the trend of FGF5 expression in PLP2 gene was positively regulated. The influence of MT on the expression of PLP2 gene was negatively regulated, and the inhibition was gradually enhanced with the passage of time. Studies have confirmed that the Noggin gene is an inhibitor of the BMP signaling pathway. After the noggin gene interferes with the lentivirus infection, the expression of the PLP2 gene is downregulated. Therefore, the PLP2 gene, along with the other suppressor genes including the noggin gene, might affect the development of hair f...Continue Reading

References

Feb 26, 2000·The Journal of Investigative Dermatology·S SuzukiT Imamura
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V A BotchkarevB A Gilchrest
Aug 19, 2003·Genes & Development·Charles K KaufmanElaine Fuchs
Oct 12, 2004·Biochemical and Biophysical Research Communications·Sang Min LeeJiyoung Kim
Jun 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chunyan MouDenis J Headon
Jun 17, 2006·The Journal of Investigative Dermatology·D Ben AmitaiZ Laron
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takayuki OkanoMatthew W Kelley
Mar 3, 2015·Genetics and Molecular Research : GMR·Y H ZhaoJ Q Li
May 20, 2017·Frontiers in Cell and Developmental Biology·Ondrej BernatikVitezslav Bryja

❮ Previous
Next ❯

Datasets Mentioned

BETA
AF481157

Methods Mentioned

BETA
PCR
reverse transcription
reverse transcription PCR
electrophoresis

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.