Expression of liver X receptors in pregnancies complicated by preeclampsia

Placenta
M S Weedon-FekjærAnne Cathrine Staff

Abstract

Preeclampsia is a pregnancy-specific disorder associated with hyperlipidemia. Liver X receptor (LXR) alpha and LXRbeta are key regulators of lipid homeostasis. In the current study, we investigated expression of LXRalpha, LXRbeta and their target genes in human term placenta, decidua and subcutaneous adipose tissue from pregnancies complicated by preeclampsia. Furthermore, we analyzed the protein levels of LXRalpha and LXRbeta in placenta. We also analyzed lipid concentrations in term placental tissue. Gene expression of LXRalpha, LXRbeta and fatty acid transporter CD36 was significantly decreased in placental tissues, while increased expression was observed for LXRalpha in adipose tissue, from pregnancies complicated by preeclampsia. The placental protein level of LXRbeta was reduced, and there was a positive correlation between placental LXRbeta mRNA expression and placental free fatty acids in preeclampsia. Our results suggest a possible role for LXRbeta as a transcriptional regulator in preeclampsia.

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Citations

Jul 4, 2012·Molecular and Cellular Endocrinology·Kevin MouzatJean-Marc Lobaccaro
Feb 7, 2015·The Journal of Obstetrics and Gynaecology Research·Jian-ying Yan, Ling-ling Jiang
Nov 16, 2010·Biochimica Et Biophysica Acta·Georgia PapacleovoulouCatherine Williamson
Apr 20, 2016·Molecular Aspects of Medicine·Salwan MaqdasyJean-Marc A Lobaccaro
Jun 22, 2016·Placenta·Ana Rita Sequeira de SousaGro Leite Størvold
Aug 10, 2016·Cellular and Molecular Life Sciences : CMLS·Aurélie ComptourVincent Sapin
Jan 1, 2013·Reproductive Sciences·Yoshitsugu ChigusaIkuo Konishi
Jul 26, 2018·International Journal of Molecular Sciences·Sarah DallelSalwan Maqdasy
Sep 28, 2018·Frontiers in Pharmacology·Waranya ChatuphonprasertIsabella Ellinger
Feb 3, 2021·The FEBS Journal·Mingyu HuChao Tong

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