Expression of Lrrn1 marks the prospective site of the zona limitans thalami in the early embryonic chicken diencephalon

Gene Expression Patterns : GEP
Elena García-CaleroL Puelles

Abstract

An unknown chicken gene selected from a published substractive hybridization screen (GenBank Accession No. ; [Christiansen, J.H., Coles, E.G., Robinson, V., Pasini, A., Wilkinson, D.G., 2001. Screening from a subtracted embryonic chick hindbrain cDNA library: identification of genes expressed during hindbrain, midbrain and cranial neural crest development. Mech. Dev. 102, 119-133.]) was deemed of interest because of its dynamic pattern of expression across the forebrain and midbrain regions. A 528bp fragment cloned from early chick embryo cDNA and used for in situ hybridization corresponded to part of the 3' untranslated region of the chicken gene Leucine-rich repeat neuronal protein 1 (Lrrn1). The expression of this gene, mapped in the embryonic chick brain between stages HH10 and HH26, apparently preconfigures the zona limitans thalami site before overt formation of this boundary structure. Apart of colateral expression in the forebrain, midbrain and hindbrain basal plate, the most significant expression of Lrrn1 was found early on across the entire alar plate of midbrain and forebrain (HH10). This unitary domain soon divides at HH14 into a rostral part, across alar secondary prosencephalon and prospective alar prosomere 3 (p...Continue Reading

References

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Mar 30, 2002·Brain Research Bulletin·Margaret Martínez-de-la-TorreLuis Puelles
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Oct 24, 2003·Brain Research. Brain Research Reviews·Diego EchevarríaSalvador Martínez
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Jan 27, 2005·The Journal of Comparative Neurology·Matías Hidalgo-SánchezLuis Puelles
Jun 17, 2005·Nature Reviews. Neuroscience·Clemens Kiecker, Andrew Lumsden
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Aug 23, 2005·Brain Research. Brain Research Reviews·Pilar Aroca, Luis Puelles
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Citations

May 23, 2012·The European Journal of Neuroscience·Yasushi Nakagawa, Tomomi Shimogori
Jul 18, 2006·Neuroscience·E García-CaleroL Puelles
Nov 5, 2016·Developmental Neurobiology·Henrik Gezelius, Guillermina López-Bendito
Oct 4, 2007·The Journal of Comparative Neurology·J L FerranL Puelles

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