Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility.

Drug Target Insights
Oskar HammarB Ohlsson

Abstract

Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of LH receptors in the gastrointestinal tract has never been described. The aim of this study was to find one possible way of action for leuprolide by examining the presence of the LH receptor, and if present, to see whether there was different expression in patients with or without dysmotility. Full-thickness biopsies from the bowel wall of patients with and without severe dysmotility were examined using immunohistochemistry staining. Biopsies showed expression of LH receptors on myenteric neurons and in glial cells, neutrophils, endothelial cells and mast cells. There was no difference in expression between patient groups.

References

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Citations

Mar 8, 2016·The Journal of Physical Chemistry. B·Matias I SanchoRicardo D Enriz
May 16, 2015·Peptides·Irene Ramos-ÁlvarezRobert T Jensen
Aug 27, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Million, M Larauche
Mar 9, 2018·Case Reports in Gastroenterology·Bodil OhlssonHenrik Thorlacius
Nov 7, 2013·BMC Pregnancy and Childbirth·Oskar HammarBodil Ohlsson
Nov 15, 2012·Scandinavian Journal of Gastroenterology·Bodil Roth, Bodil Ohlsson
Dec 17, 2014·BMC Gastroenterology·Elin SandBodil Ohlsson
Jun 24, 2017·Frontiers in Endocrinology·Bodil Ohlsson
Jan 17, 2015·Scandinavian Journal of Gastroenterology·Lina CordedduBodil Ohlsson

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Methods Mentioned

BETA
biopsy
biopsies

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