PMID: 20646540Jul 22, 2010Paper

Expression of macrophage migration inhibitory factor and CD74 in preeclamptic placenta and its correlation with preeclampsia

Zhonghua fu chan ke za zhi
Xiao-fang XieYan Zhang

Abstract

To investigate the expression of macrophage migration inhibitory factor (MIF) and CD74, the receptor of MIF, in preeclamptic placenta and its correlation with the pathogenesis of preeclampsia. From March 2008 to November 2008, 69 preeclamptic women who delivered in the Department of Obstetrics, Affiliated Hospital of Qingdao University Medical College, were recruited, including 33 women with mild preeclampsia (MPE group) and 36 women with severe preeclampsia (SPE group). Another 43 healthy pregnant women were taken as control group. Immunoturbidimetry was applied to measure the concentrations of C-reactive protein (CRP) in maternal blood. The expressions of MIF and CD74 in placenta were tested with immunohistochemistry and the expressions of MIF mRNA and CD74 mRNA were detected by semiquantitative RT-PCR. The relationship between maternal blood level of CRP and MIF mRNA and CD74 mRNA in placenta was analyzed in the MPE and SPE group. (1) MIF and CD74 were expressed in the placenta of all pregnant women in the 3 groups, as shown in brown-yellow color, and significantly higher expression was found in the MPE and SPE group. (2) The expression of MIF mRNA and CD74 mRNA in the MPE group (0.70+/-0.13 and 0.96+/-0.16), SPE group (0.88...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.