PMID: 9646034Jul 1, 1998Paper

Expression of macrophage migration inhibitory factor in the human prostate

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
Katherine L Meyer-SieglerP B Hudson

Abstract

The expression of macrophage migration inhibitory factor (MIF) in prostate tissue was investigated by immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), and Northern blot analysis using a prostate tissue bank. MIF expression was examined in each of the following established prostate tissue categories: prepubertal, pubertal, adult normal, benign hyperplastic (BPH), focal carcinoma within the prostate, and metastatic prostate cancer. IHC showed that all samples tested were positive for MIF protein, which localized to the glandular epithelial cells with no apparent staining of stroma. The most intense staining was observed in the metastatic prostatic adenocarcinoma and the human prostatic adenocarcinoma cell line LNCaP. Using quantitative ELISA, MIF expression was found to be at least three times higher in metastatic adenocarcinoma than in normal, BPH, or focal carcinoma in the adult prostate. This study is the first to report that prostate glandular epithelial cells express MIF. The exact role of MIF in prostate development and disease progression requires further study.

References

Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·L W ChungJ S Rubin
Jan 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·E P Diamandis
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G J WistowP S Zelenka
Oct 20, 1993·Journal of the National Cancer Institute·N M NavoneC J Conti
Feb 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·O Melefors, M W Hentze
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·G WaeberR Bucala
Jun 9, 1997·Biochemical and Biophysical Research Communications·J HirokawaJ Nishihira

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Citations

Nov 11, 2003·Cellular Signalling·Robert A Mitchell
Apr 21, 2005·The Journal of Biological Chemistry·James D SwantRobert A Mitchell
Nov 24, 1999·The Journal of Experimental Medicine·C Cordon-Cardo, C Prives
Oct 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K Meyer-Siegler
Mar 7, 2014·British Journal of Cancer·C OtterstromV Serre-Beinier
Jan 14, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Nuri YildirimCumhur Gunduz
May 21, 2009·Experimental and Molecular Pathology·Magdalena M DaileyJohn O Trent
Feb 3, 2009·Experimental and Molecular Pathology·Beatriz E RendonRobert A Mitchell
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Mar 2, 2011·Journal of Neuroscience Research·Nina BaronMichael Bacher
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Nov 26, 2015·Molecular Medicine·Jason A Chesney, Robert A Mitchell
Oct 28, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason MartinAnne M VanBuskirk
Feb 18, 2016·Oncotarget·Cintia D'Amato-BritoVéronique Serre-Beinier
Feb 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sofia LourencoSam M Janes
Nov 6, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kendra D SimpsonJanet V Cross
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