Expression of major histocompatibility complex class II antigens in porcine leptospiral nephritis

Veterinary Pathology
E RadaelliE Scanziani

Abstract

Class II major histocompatibility complex (MHCII) is required for the presentation of antigens to CD4 helper T cells. During nephritis, not only primary antigen presenting cells such as histiocytes and lymphocytes, but also cytokine-stimulated tubular epithelial cells express MHCII. Leptospirosis in fattening pigs is characterized by several degrees of nephritis, from absence of lesions to severe multifocal tubulo-interstitial inflammation. Renal tissue from 20 8-month-old pigs with spontaneous nephritis and 6 control pigs without renal lesions were investigated for leptospirosis by indirect immunohistochemistry (IHC) and polymerase chain reaction (PCR). IHC for MHCII also was performed on renal samples. Serum samples were tested for different serovars of Leptospira interrogans. Control pigs were free of interstitial nephritis and negative for leptospirosis by all tests. In pigs with nephritis, serology was positive for serovar Pomona in 19/20 pigs. In 16 of these 19 pigs, leptospiral renal infection was confirmed by PCR and/or indirect IHC. Nephritic lesions were classified histologically into perivascular lymphocytic (4 pigs), lymphofollicular (6 pigs), lymphohistiocytic (8 pigs), and neutrophilic (2 pigs) pattern. MHCII expr...Continue Reading

References

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Citations

Jan 10, 2012·Veterinary Immunology and Immunopathology·M PezzolatoE Radaelli
Sep 8, 2017·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Ines SpiekermeierWolfgang Baumgärtner
May 18, 2017·Frontiers in Immunology·Maria Carmina CastielloMarita Bosticardo

Related Concepts

Immune-Associated Antigens
DNA, Bacterial
Immunocytochemistry
Leptospirosis
Nephritis, Tubulointerstitial
Swine Diseases
Nested Polymerase Chain Reaction
Spearman Rank Correlation Coefficient
Leptospira interrogans serovar pomona
Antigen-Presenting Cells

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