PMID: 3320179Oct 1, 1987Paper

Expression of major histocompatibility complex class II antigens on bile duct epithelium in patients with hepatic graft-versus-host disease after bone marrow transplantation

Journal of Hepatology
F MiglioG Gasbarrini

Abstract

We studied the expression of major histocompatibility complex (MHC) class II antigens in liver biopsies taken from ten patients with clinical and biochemical evidence of liver damage after bone marrow transplantation. In all six patients who had histologically confirmed graft-versus-host disease, MHC class II antigens were detected on intrahepatic bile ducts. In four patients with no histological features of graft-versus-host disease, MHC class II antigens were not detected. In controls, a positive reaction for bile duct MHC class II antigens was only detected in the patients with primary biliary cirrhosis. Characterisation of the lymphocytes surrounding the bile ducts showed a prevalence of Leu 3+ cells in graft-versus-host disease and primary biliary cirrhosis. We propose that the aberrant expression of class II antigens on bile duct epithelium cells may play a role in the pathogenesis of graft-versus-host disease. A similar pattern in primary biliary cirrhosis may suggest a common pathogenetic mechanism.

References

May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PignatelliH C Thomas
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C SnoverJ H Kersey
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Citations

Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L SaidmanA J Demetris
May 1, 1996·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·H R RosenR W Busuttil
Feb 20, 2007·HIV Medicine·S HindupurN Kirmani
Sep 11, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gaurav SyalJonathan A Dranoff
Dec 1, 1996·The Journal of Laboratory and Clinical Medicine·W HuH L Sharp
Dec 18, 2007·Journal of Pediatric Surgery·Makoto HayashidaTomoaki Taguchi
Jul 30, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Claudio PintoMarco Marzioni
Sep 1, 1991·Postgraduate Medical Journal·P ButlerA K Burroughs

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