PMID: 9004075Nov 1, 1996Paper

Expression of major histocompatibility complex class II molecules by dermal inflammatory cells, epidermal Langerhans cells and keratinocytes in canine dermatological disease

Journal of Comparative Pathology
M J Day

Abstract

The distribution of Major Histocompatibility Complex (MHC) Class II molecules in skin biopsies from 42 dogs with primary skin disease and six control dogs was examined by indirect immunohistochemical methods. Canine epidermal Langerhans cells constitutively expressed MHC Class II and the number of such cells was increased in the epidermis of dogs with discoid lupus erythematosus (n = 10), hypersensitivity dermatitis (n = 10) or deep pyoderma (n = 13) but not in eight cases of pemphigus foliaceus. Expression of MHC Class II by epidermal and follicular keratinocytes was observed in a ninth dog with pemphigus foliaceus. Within dermal inflammatory infiltrates, Class II was expressed by macrophages, dendritic cells and fibroblasts but not by neutrophils, eosinophils, mast cells or plasma cells. Only occasional dermal lymphocytes expressed surface MHC Class II, but nodular aggregates of strongly Class II-positive lymphocytes were observed within the dermis of two dogs with discoid lupus erythematosus.

Citations

Feb 1, 1997·Journal of Comparative Pathology·M J Day
Oct 3, 2003·Veterinary Immunology and Immunopathology·M SpeetiE Westermarck
Jun 5, 1998·Veterinary Immunology and Immunopathology·A J GermanM J Day
Jun 18, 2011·Pharmacogenetics and Genomics·Geo SeminiKerstin Danker
Sep 20, 2002·The Journal of Small Animal Practice·M J Day, M W S Martin
Jul 4, 2001·Australian Veterinary Journal·M KleiterM J Day
Jan 11, 2007·Journal of Clinical Pathology·Mahmoud R HusseinAbd-Elhady M M Omar
Oct 9, 2007·Journal of Comparative Pathology·K TaglingerA P Foster
Jul 3, 2007·Veterinary Immunology and Immunopathology·Maike HuisingaManfred Reinacher
Oct 24, 2009·Experimental Dermatology·Alexander SchönefussChristine Stichel
May 17, 2005·Journal of Comparative Pathology·D PeetersC Clercx
Jan 15, 2008·Veterinary Ophthalmology·M J DayW J Carter
Mar 3, 2015·Veterinary Dermatology·Cherie M Pucheu-HastonTim Nuttall
Jul 16, 2005·Pathologie-biologie·C Miranda de CarvalhoL Chabanne
Nov 17, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M ChristgauR N D'Souza

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