Expression of matrix metalloproteinase-9 mRNA in osteoporotic bone tissues

Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
H ZhaoT Zhu

Abstract

Matrix metalloproteinases (MMPs), a sort of important enzymes involved in extracellular matrix metabolism, play critical roles in the process of tissues remodeling, wound healing and metastasis of tumors. Dot blot and in situ hybridization were used in this study to detect the expression and localization of MMP-9, an important proteolytic enzyme implicated in bone resorption in bone tissues. The results showed that the level of MMP-9 mRNA expression in osteoporotic bone tissues was significantly higher than that in normal control group and the cell types that expressed MMP-9 mRNA included mono- and multi-nuclear osteoclasts and some lining cells on the surface of bone matrix. It was suggested that MMP-9 play a key role in the development of bone loss in osteoporosis.

References

Jul 1, 1992·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·J E Emery
Aug 1, 1992·Matrix : Collagen and Related Research·J A LorenzoM S Hibbs
Apr 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A L WucherpfennigP Stashenko
Feb 15, 1993·Biochemical and Biophysical Research Communications·H TanakaK Sugita
May 1, 1993·Biological Reviews of the Cambridge Philosophical Society·M ZaidiM Pazianas

❮ Previous
Next ❯

Citations

Oct 22, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tessa LuhmannLorenz Meinel
May 18, 2007·Journal of Cellular Physiology·V SamannaM A Chellaiah
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jeffry S NymanGregory R Mundy
Apr 7, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Neetu TyagiSuresh C Tyagi
Dec 22, 2011·Journal of Pharmacological Sciences·Yoshiomi OkaKatsuji Oguchi
Apr 9, 2005·Archives of Gerontology and Geriatrics·D MaugeriP Panebianco
Sep 7, 2018·Experimental and Therapeutic Medicine·Xuefeng ZhengYanping Lin
Mar 3, 2020·Frontiers in Physiology·Eugenio Hardy, Carlos Fernandez-Patron
Jan 1, 2012·Journal of Pharmacological Sciences·Yoshiomi OkaKatsuji Oguchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Shijing QiuA Michael Parfitt
Indian Journal of Clinical Biochemistry : IJCB
Vanita R JagtapNitin S Nagane
© 2022 Meta ULC. All rights reserved