Expression of Mcl-1 and p53 proteins predicts the survival of patients with T3 gastric carcinoma

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Yoshihiko MaetaNobuaki Kaibara

Abstract

The expression of myeloid cell leukemia 1 (Mcl-1) and p53 proteins was investigated for clinicopathological and prognostic significance in patients with gastric carcinoma. Mcl-1 protein was immunohistochemically examined in 182 patients with gastric carcinoma. The overexpression of p53 was also analyzed in T3 gastric carcinomas. The expression of Mcl-1 was detected in 127 (69.8%) patients with gastric carcinoma. Mcl-1 was detected significantly more frequently in the undifferentiated type ( P < 0.05) and in the advanced stage of disease ( P < 0.05). The prognosis of patients with an Mcl-1-positive tumor was significantly worse than that of those with an Mcl-1-negative tumor ( P < 0.05). Multivariate analysis revealed that the expression of Mcl-1 was an independent prognostic factor, as were lymph node metastasis and tumor size. There was no significant relationship between the expression of Mcl-1 and p53. In patients with T3 gastric carcinoma who underwent curative surgery; however, Mcl-1(-)/p53 (-) tumor demonstrated the best postoperative survival rate, whereas Mcl-1(+)/p53(+) tumor had the worst. The expression of Mcl-1 is an indicator of tumor progression and postoperative recurrence in patients with gastric carcinoma. Comb...Continue Reading

Citations

Apr 25, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideko AkagiToshifumi Hibi
Aug 23, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·D M PritchardA Varro
Feb 13, 2015·International Journal of Oncology·Wan-Sik LeeYoung-Eun Joo
Dec 18, 2009·Journal of Cellular and Molecular Medicine·Anna TeseiWainer Zoli
Sep 25, 2012·International Journal of Cancer. Journal International Du Cancer·Yoshimasa SaitoToshifumi Hibi
Jun 4, 2011·Cell Biology International·Alžběta JugováEva Bártová

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