PMID: 7537927Jan 1, 1995Paper

Expression of mdm-2 and p53 protein in transitional cell carcinoma

Urological Research
M BarbareschiP Dalla Palma

Abstract

Amplification of the mdm-2 gene and overexpression of the mdm-2 protein might inactivate p53 function, and may have prognostic relevance. The present paper investigated the immunohistochemical overexpression of the mdm-2 and p53 proteins in 25 biopsy specimens of transitional cell bladder carcinomas (10 pT1 and 15 pT2 or higher stages). Five cases (20%) showed strong mdm-2 protein immunoreactivity in more than 5% of the tumor cells; 14 cases (56%) showed p53 immunoreactivity in more than 20% of the cells, and were considered as overexpressing p53 protein. Four of the five cases with strong mdm-2 immunoreactivity did not show p53 overexpression, and 13 of the 14 cases with p53 overexpression did not show mdm-2 immunoreactivity. Our data are consistent with the hypothesis that p53 overaccumulation (and hence possible p53 gene mutation) or mdm-2 overexpression (and hence possible mdm-2 gene amplification) may mirror two different and possibly complementary gene alterations, which might finally interfere with the control of cell proliferation and apoptosis. In this perspective, evaluation of the combined mdm-2/p53 protein phenotype in human bladder carcinomas could have prognostic relevance and give us better prognostic information...Continue Reading

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Citations

Sep 6, 2000·Urologic Oncology·B J Schmitz-DrägerM Heydthausen
Jan 6, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·C Cordon-CardoG Sauter
Jul 9, 2010·Urologic Oncology·Peter J GoebellUNKNOWN International Study-Initiative on Bladder Cancer (ISBC)
Mar 4, 2000·The Urologic Clinics of North America·F Rabbani, C Cordon-Cardo
Dec 5, 1998·British Journal of Urology·P E KeeganD E Neal
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elena López-KnowlesUNKNOWN EPICURO Study Investigators

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