Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus

Neuroendocrinology
Lourdes MounienS Jégou

Abstract

Neuropeptide Y (NPY) and alpha-melanocyte-stimulating hormone (alpha-MSH), two neuropeptides that are synthesized in neurons of the arcuate nucleus of the hypothalamus, exert opposite actions on food intake and body weight. NPY is orexigenic and decreases energy expenditure whereas alpha-MSH reduces food consumption and stimulates catabolism. alpha-MSH is an endogenous ligand for the central melanocortin receptors, MC3-R and MC4-R. In order to determine whether alpha-MSH may act directly on NPY neurons in the arcuate nucleus, we have investigated the possible occurrence of MC3-R and MC4-R mRNA in NPY-expressing cell bodies in the rat hypothalamus. Double-labeling in situ hybridization histochemistry using (35)S-labeled (MC3-R or MC4-R) and digoxigenin-labeled (NPY) riboprobes revealed that 38 +/- 1% of the NPY mRNA-positive perikarya expressed MC3-R mRNA while only 9 +/- 2% of the NPY-producing neurons contained MC4-R mRNA. The proportions of NPY neurons that express MC3-R mRNA or MC4-R mRNA were not significatively different in the anterior and posterior aspects of the arcuate nucleus. The present study shows that a large proportion of NPY neurons in the rat hypothalamus express MC3-R mRNA while a much lower number of NPY neur...Continue Reading

References

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Citations

Jun 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lourdes MounienSylvie Jégou
Mar 8, 2008·Nature Reviews. Drug Discovery·Jarl E S Wikberg, Felikss Mutulis
Sep 4, 2007·Nutrition & Metabolism·George Wm Millington
Jul 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Ying Fu, Anthony N van den Pol
Jul 11, 2014·Journal of Chemical Neuroanatomy·M M H van SwietenG van der Plasse
Jan 23, 2016·Endocrinology and Metabolism·Ye Ran Yoon, Ja Hyun Baik
Jan 8, 2011·European Journal of Pharmacology·Benjamin J RenquistRoger D Cone
Dec 29, 2009·Behavioural Brain Research·Clémence Blouet, Gary J Schwartz
Dec 26, 2006·Regulatory Peptides·Biaoxin ChaiMichael W Mulholland
May 18, 2013·Biochimica Et Biophysica Acta·Clemence Girardet, Andrew A Butler
Oct 29, 2013·Brain Research·Jin Kwon Jeong, Sabrina Diano
May 23, 2015·Frontiers in Cellular Neuroscience·Adel DerghalLourdes Mounien
Jul 6, 2011·Frontiers in Neuroendocrinology·Rebecca E MercerWilliam F Colmers
May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Feb 14, 2019·Translational Psychiatry·Nicolas LucasSergueï O Fetissov
Jun 24, 2019·Steroids·Todd L StincicMartin J Kelly

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