Expression of metastasis-associated protein 2 (MTA2) might predict proliferation in non-small cell lung cancer.

Targeted Oncology
Shu-Li LiuShun-Dong Dai

Abstract

Metastatic tumor antigen 2 (MTA2) is a member of the MTA family that is closely associated with tumor progression and metastasis. In this study, the expression profile of MTA2 in 223 cases of non-small cell lung cancer (NSCLC) tissues and two lung cancer cell lines was investigated. Interestingly, we found MTA2, which was believed to have nuclear distribution only, was distributed in both nucleus and cytoplasm in normal and cancer cells. Nuclear MTA2 expression was detected in 148 cases of NSCLC (66.4%), and was correlated with advanced TNM stages (p=0.023), tumor size (p=0.036), and lymph node metastasis (p=0.004). Besides, the Ki-67 proliferation index was significantly higher in nuclear MTA2-positive tumors than in nuclear MTA2-negative tumors (r=0.538, p=0.006). However, there was no significant difference in cytoplasmic MTA2 status by age, gender, tumor stage, histology, grade, lymph node metastasis, and Ki-67 proliferation index. Univariate analysis revealed nuclear MTA2 expression was correlated with poor overall survival (p=0.035), whereas there was a nonsignificant trend in the same direction for cytoplasmic MTA2 (p=0.134). Multivariate Cox regression analysis revealed the overexpression of nuclear and cytoplasmic MTA2...Continue Reading

References

Apr 17, 1999·British Journal of Cancer·Y TohK Sugimachi
Jan 24, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hidefumi SasakiYoshitaka Fujii
Nov 13, 2003·Seminars in Oncology·Rakesh KumarRozita Bagheri-Yarmand
Feb 12, 2004·Cancer Research·Matthias D HoferMark A Rubin
Mar 17, 2004·Biochimica Et Biophysica Acta·Nathan J BowenPaul A Wade
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Jan 5, 2008·Nuclear Receptor Signaling·Bramanandam ManavathiRakesh Kumar
Jul 21, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shun-Dong DaiEn-Hua Wang
Mar 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jonathan Sleeman, Patricia S Steeg
Jul 28, 2010·Expert Review of Respiratory Medicine·Subhankar ChakrabortySurinder K Batra

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Citations

Jul 5, 2013·PloS One·Sara Martoreli SilveiraSilvia Regina Rogatto
Nov 16, 2014·Cancer Metastasis Reviews·Jian LiuHaili Qian
Nov 7, 2014·Cancer Metastasis Reviews·Ekjot KaurShilpee Dutt
Oct 25, 2014·Cancer Metastasis Reviews·Zhifeng NingHao Zhang
May 24, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Shouqin ShanJinfeng Liu
Jul 31, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tsai-Yi TsengYi-Hsien Hsieh
Jul 24, 2020·International Journal of Cancer. Journal International Du Cancer·Soha A HassanCharlotte von Gall
May 11, 2018·Cancer Cell International·Jia-Xiang AnDong-Qiu Dai
Aug 21, 2020·Cancer Research·Nefertiti El-NikhelyRajkumar Savai
Jul 2, 2021·Cell Reports Medicine·Soulaimane AboulouardMichel Salzet

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