PMID: 6972360Nov 15, 1980Paper

Expression of metastatic potential of tumor cells in young nude mice is correlated with low levels of natural killer cell-mediated cytotoxicity

International Journal of Cancer. Journal International Du Cancer
N Hanna

Abstract

Of 6- and 3-week-old nude mice given intravenous injections of murine tumor cells with well-defined metastatic properties, only the 3-week-old mice developed lung tumor colonies in significant numbers. The quantitative differences in metastatic potential among tumor cell lines injected into syngeneic recipients were also maintained following intravenous injection into young nude mice. Successful metastasis in 3-week-old nude mice is correlated with the low levels of natural killer cell activity detected in these young recipients. Boosting of the natural killer cell activity of 3-week-old nude mice by the administration of bacterial adjuvants and interferon inducers significantly inhibited metastasis formation. The differences in metastasis development could not be attributed to differences in the initial arrest of tumor cells in the pulmonary vascular bed, but rather to a better survival of the arrested cells in the lungs of 3-weeks-old nude mice as compared with 6-week-old counterparts. We concluded that low levels of NK cell activity are associated with increased incidence of experimental metastasis.

References

Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R B HerbermanD H Lavrin
Nov 15, 1979·International Journal of Cancer. Journal International Du Cancer·E A ClarkM A Horton
Jan 1, 1978·Advances in Cancer Research·R B Herberman, H T Holden
Jan 1, 1979·Immunological Reviews·R Kiessling, H Wigzell
Dec 1, 1979·Cancer Treatment Reviews·T J Priestman
Mar 15, 1979·International Journal of Cancer. Journal International Du Cancer·A P KyriazisA J Pesce
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·R B HerbermanJ Y Djeu
Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·S E Martin, W J Martin
Jan 1, 1976·Journal of the National Cancer Institute·C B SkovE H Perkins
Jan 15, 1973·International Journal of Cancer. Journal International Du Cancer·C O PovlsenF Wiener
Apr 4, 1973·Nature: New Biology·I J Fidler
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
May 1, 1974·Journal of the National Cancer Institute·L OzzelloJ P Mach
Apr 15, 1974·International Journal of Cancer. Journal International Du Cancer·M Olivotto, R Bomford
Jan 1, 1969·Acta Pathologica Et Microbiologica Scandinavica·J Rygaard, C O Povlsen
Oct 1, 1980·Journal of the National Cancer Institute·N Hanna, I J Fidler
Apr 17, 1980·Nature·J E TalmadgeJ R Starkey

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Citations

Jun 1, 1997·Journal of Surgical Oncology·T C Chao, J A Greager
Nov 1, 1988·Cancer Metastasis Reviews·J MatternM Volm
Jan 1, 1982·Cancer Metastasis Reviews·G Poste
Jan 1, 1982·Cancer Metastasis Reviews·N Hanna
Jan 1, 1984·Cancer Metastasis Reviews·F E Sharkey, J Fogh
Apr 1, 1987·Clinical & Experimental Metastasis·S NaitoI J Fidler
Mar 1, 1993·Clinical & Experimental Metastasis·G G MeadowsL J Pfister
Jan 1, 1986·Cancer Chemotherapy and Pharmacology·G G MeadowsJ R Starkey
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·K KayserH D Becker
Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·G Poste, R Greig
Nov 1, 1992·Cancer Metastasis Reviews·H C Kwaan
Apr 1, 1989·Diseases of the Colon and Rectum·W BirsicA Katoh
Dec 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·B J DruckerW D Holder
Mar 10, 2010·Cell Biology and Toxicology·Fred D DudimahMargaret M Whalen
Jan 15, 2011·Clinical & Experimental Metastasis·Hui ZhangGary G Meadows
Jan 1, 1989·International Journal of Immunopharmacology·D D MickeyK Foulkes
Aug 1, 1985·The Journal of Experimental Medicine·P D ShahD A Rowley
Feb 23, 2012·International Immunology·Connie JackamanDelia J Nelson
Jan 16, 1999·Journal of the National Cancer Institute·M HejnaC C Zielinski
Apr 29, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Margaret M WhalenRobert W Luebke
Jan 1, 1990·Immunopharmacology and Immunotoxicology·P M Renzi, L C Ginns
Mar 20, 2010·Journal of Immunotoxicology·Felicia UdojiMargaret M Whalen
Sep 30, 2008·Drug and Chemical Toxicology·Jeralyn J PowellMargaret M Whalen
Dec 1, 1986·The American Journal of the Medical Sciences·J SanchezD M Miller
Jul 30, 1991·International Journal of Cancer. Journal International Du Cancer·D A LoefflerG H Heppner
Jan 6, 2009·Environmental Toxicology and Pharmacology·Laurin N HollowayMargaret M Whalen

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