PMID: 8946684Oct 1, 1996Paper

Expression of MHC class I and class II antigens in pancreatic adenocarcinomas

Tissue Antigens
M T ScupoliR S Accolla

Abstract

The antigens encoded by the major histocompatibility complex (MHC) are cell surface glycoproteins that play a fundamental role in the regulation of the immune response. Anomalous MHC expression in tumor cells has been viewed as an important feature to escape tumor recognition by immune cells. Low or absent MHC class I expression as well as ectopic MHC class II expression have been often observed to correlate with high grade malignancy and metastatic potential in a variety of human cancers. To date, very little investigation of MHC (HLA in man) class I and class II expression in human pancreatic cancer has been reported. We investigated this aspect on frozen sections of 8 pancreatic adenocarcinomas and 18 established in vitro cell lines. HLA class I was expressed in all but two cancers whereas de novo HLA class II expression was detected in 3 of 8 cancers. Interestingly, a hierarchy in the expression of the various subsets of HLA class II was found with HLA- DR > -DP > -DQ. Results on cell lines strongly resembled the ones obtained in cancer tissues. However, a peculiar feature was observed in certain cell lines. HLA class II antigens were expressed in only a few cell lines and in some of them a mixed population of positive and ...Continue Reading

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Citations

Aug 12, 2005·Cancer Immunology, Immunotherapy : CII·Graziella BelloneGiorgio Emanuelli
Sep 2, 2006·Cancer Immunology, Immunotherapy : CII·Kuichun ZhuDavid Z Chang
Mar 15, 2000·Human Immunology·M P PistilloG B Ferrara
Apr 20, 2016·Journal of Translational Medicine·Greta ForlaniGiovanna Tosi
Jun 25, 2005·Brain : a Journal of Neurology·Manuel A Friese, Lars Fugger
Dec 14, 2004·Springer Seminars in Immunopathology·Pierre Guermonprez, Sebastian Amigorena
Nov 29, 2011·Virchows Archiv : an International Journal of Pathology·Matthias M GaidaFrank Bergmann
Sep 5, 2001·Clinical and Experimental Immunology·M TommasiM Colombatti
Sep 24, 2020·Molecular & Cellular Proteomics : MCP·Greta ForlaniMichal Bassani-Sternberg
Feb 17, 2021·Molecular & Cellular Proteomics : MCP·Greta ForlaniMichal Bassani-Sternberg
Aug 3, 2021·Frontiers in Immunology·Eric de SousaMarkus Maeurer

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