PMID: 25773834Mar 17, 2015Paper

Expression of microRNA-218 and its clinicopathological and prognostic significance in human glioma cases

Asian Pacific Journal of Cancer Prevention : APJCP
Mao-Wei ChengGu-Yu Hu

Abstract

MicroRNAs are a class of noncoding RNAs which regulate multiple cellular processes during tumor development. The purpose of this report is to investigate the clinicopathological and prognostic significance of miR-218 in human gliomas. Quantitative RT-PCR (qRT-PCR) was conducted to detect the expression of miR-218 in primary normal human astrocytes, three glioma cell lines and 98 paired glioma and adjacent normal brain tissues.Associations of miR-218 with clinicopathological variables of glioma patients were statistically analyzed. Finally, a survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. The expression level of miR-218 in primary normal human astrocytes was significantly higher than that in glioma cell lines (p<0.01). Also, the expression level of miR-218 in glioma tissues was significantly downregulated in comparison with that in the adjacent normal brain tissues (p<0.001). Statistical analyses demonstrated that low miR-218 expression was closely associated with advanced WHO grade (p=0.002) and low Karnofsky performance score (p=0.010) of glioma patients. Kaplan-Meier analysis with the log-rank test showed that patients with low-miR-218 expression had poorer disease-free sur...Continue Reading

References

Aug 23, 2005·Gene·Fabrício F Costa
Mar 7, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Cinzia SevignaniCarlo M Croce
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Dec 17, 2009·Cancer Metastasis Reviews·Sylvia K Shenouda, Suresh K Alahari
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Ying ZhangRoger Abounader
Aug 18, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Longqiu YangLei Zhang
Dec 6, 2012·The Journal of Biological Chemistry·Sujatha VenkataramanRajeev Vibhakar
May 7, 2013·Cancer Chemotherapy and Pharmacology·Jie WangZhong-ping Chen
Nov 26, 2013·Methods in Molecular Biology·Kemal Uğur TüfekciSermin Genç
Dec 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lijoy K MathewM Celeste Simon
Mar 14, 2014·Medical Oncology·Jun SunXiaojie Lu
Aug 21, 2014·Journal of Neuro-oncology·Wanghao ChenQiaoyu Li

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Citations

May 15, 2019·Medicine·Yunyang LiuXinyu Yang
Sep 1, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fereshteh AhmadinejadHossein Teimori
Jul 28, 2016·Oncotarget·Katharina IlmUlrike Stein
Mar 31, 2021·Proceedings of the National Academy of Sciences of the United States of America·Si-Yao LuJun Yao

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