Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Shihua YaoHai Jin

Abstract

MicroRNAs (miRNAs) can function as tumor suppressors and might provide an efficient strategy for annihilating cancer. Nevertheless, the potential role of miR-325-3p in NSCLC is still unknown. Here, we showed that miR-325-3p was decreased and HMGB1 was increased in 107 NSCLC patients. MiR-325-3p inhibition promoted cell invasion and proliferation, while miR-325-3p upregulation inhibited cell invasion and proliferation by using transwell and CCK8 assays. Using a bioinformatics method, we further showed that HMGB1 might be a direct target of miR-325-3p and is negatively regulated by miR-325-3p. Down-regulation of miR-325-3p predicts poor prognosis for NSCLC patients. These findings implied that miR-325-3p regulates cell invasion and proliferation via targeting HMGB1 and may be a potential prognostic marker for NSCLC.

References

Aug 15, 1988·Biochemical and Biophysical Research Communications·E A Alexandrova, B G Beltchev
Jun 17, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Julio Sánchez de CosManuel Hernández Valle
Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Somesh Baranwal, Suresh K Alahari
Dec 2, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Richard HummelJoerg Haier
May 15, 2010·Expert Review of Molecular Diagnostics·Muller Fabbri
Jul 29, 2010·Cancer Research·Derek M Dykxhoorn
Aug 21, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yong LiuYuanzheng Qiu
Jan 6, 2011·Expert Opinion on Therapeutic Targets·Hitoshi OhmoriHiroki Kuniyasu
Feb 19, 2011·Journal of Experimental & Clinical Cancer Research : CR·Hai-Bo BianWei De
Mar 4, 2014·PloS One·Jianbiao XiaoBin Chen
Apr 1, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Dinç SürenCem Sezer
May 9, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F XuB Qian
Jul 19, 2014·Critical Reviews in Clinical Laboratory Sciences·Nathan L PriceCarlos Fernández-Hernando
Aug 15, 2014·Genetics and Molecular Research : GMR·T-Y WangW-J Yao
Aug 16, 2014·Virchows Archiv : an International Journal of Pathology·Mi Kyeong KimHyoun Wook Lee
Aug 30, 2014·World Journal of Gastroenterology : WJG·Li-Li WangChuan-Xin Wang
Sep 19, 2014·World Journal of Gastrointestinal Oncology·Ambedkar Raj Kulandai VeluIlavarasi Sinduja

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Citations

Jan 19, 2016·Life Sciences·Kaijun HuangDavid Zhang
Jun 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ruiguang ZhangXiu Nie
Jul 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Karthik Subramanian ChandrasekaranDevarajan Karunagaran
Apr 18, 2018·Journal of Cellular Biochemistry·Xiao-Jin WuDong-Sheng Pei
Feb 26, 2019·Journal of Cellular Physiology·Yong ZhangXiaoming Lei
Nov 5, 2019·Journal of Cellular Biochemistry·Yuzhuo WangMin Hu
Apr 14, 2018·BioMed Research International·Jianing YanXiujun Cai
Jul 1, 2020·Clinical and Experimental Pharmacology & Physiology·Jiping SunShifeng Yang
Dec 31, 2019·BioMed Research International·Xiaojie YuTiansheng Sun
Sep 5, 2018·Technology in Cancer Research & Treatment·Tao LinLijiang Sun
Oct 28, 2020·Journal of Cellular Physiology·Jiaming XueHaining Yang
Sep 15, 2019·Biochemical and Biophysical Research Communications·Rui LiHuaiquan Gao
Nov 24, 2020·Therapeutic Advances in Medical Oncology·Liaoran NiuDaiming Fan
Apr 27, 2021·Cancer Biomarkers : Section a of Disease Markers·Keatdamrong JanpipatkulArthit Chairoungdua

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