Expression of microRNA-99a-3p in Prostate Cancer Based on Bioinformatics Data and Meta-Analysis of a Literature Review of 965 Cases

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Hai-Biao YanGang Chen

Abstract

BACKGROUND microRNAs (miRNAs) have a role as biomarkers in human cancer. The aim of this study was to use bioinformatics data, and review of cases identified from the literature, to investigate the role of microRNA-99a-3p (miR-99a-3p) in prostate cancer, including the identification of its target genes and signaling pathways. MATERIAL AND METHODS Meta-analysis from a literature review included 965 cases of prostate cancer. Bioinformatics databases interrogated for miR-99a-3p in prostate cancer included The Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO), and ArrayExpress. Twelve computational predictive algorithms were developed to integrate miR-99a-3p target gene prediction data. Bioinformatics analysis data from Gene Ontology (GO), the Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network analysis were used investigate the possible pathways and target genes for miR-99a-3p in prostate cancer. RESULTS TCGA data showed that miR-99a was down-regulated in prostate cancer when compared with normal prostate tissue. Receiver-operating characteristic (ROC) curve area under the curve (AUC) for miR-99a-3p was 0.660 (95% CI, 0.587-0.732) or a moderate level of discriminations. Pathway...Continue Reading

Citations

Mar 21, 2019·Journal of Experimental & Clinical Cancer Research : CR·Zhe WangMargot Zöller
Mar 24, 2021·Prostate Cancer and Prostatic Diseases·Ozel CapikOmer Faruk Karatas

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Datasets Mentioned

BETA
E-MTAB-408
TCGA

Methods Mentioned

BETA
chip
RNA-seq

Software Mentioned

STRING
PITA
R
DESeq
SPSS
Cytoscape
DAVID Bioinformatics Tool
Search Tool for the Retrieval of Interacting ( STRING )

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