Expression of microRNA‑377 and microRNA‑192 and their potential as blood‑based biomarkers for early detection of type 2 diabetic nephropathy

Molecular Medicine Reports
Ghada Al-Kafaji, Haifa Abdulla Al-Muhtaresh

Abstract

The increased incidence of diabetic nephropathy (DN) in type 2 diabetes (T2D) requires novel markers for the early detection of DN. Previously, microRNAs (miRs) have been demonstrated to be promising disease biomarkers. The present study evaluated the biomarker potential of DN‑associated miR‑377 and miR‑192 in the early stages of DN. The study included 85 participants: 55 patients with T2D (30 without DN and 25 with DN) and 30 healthy controls. The patients with T2D were classified according to albumin‑to‑creatinine ratio and were split into three groups: Normoalbuminuric group (n=30), microalbuminuric group (n=15) and macroalbuminuric group (n=10). Reverse transcription‑quantitative polymerase chain reaction analysis was used to evaluate blood miR expression. It was observed that there was higher miR‑377 expression and lower miR‑192 expression in T2D patients with and without DN compared with healthy controls (P<0.05). miR‑377 was higher in the normoalbuminuric group and gradually increased in the microalbuminuric and macroalbuminuric groups (P<0.05), whereas miR‑192 was lower in the macroalbuminuric group compared with the normoalbuminuric group (P<0.05). Regression analysis revealed direct associations between the two miRs a...Continue Reading

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Nov 22, 2018·Disease Models & Mechanisms·Carmen Hurtado Del PozoNuria Montserrat

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