Expression of MicroRNAs in Periodontal and Peri-Implant Diseases: A Systematic Review and Meta-Analysis.

International Journal of Molecular Sciences
Farah Asa'adLena Larsson

Abstract

The purpose of this review was to evaluate the expression patterns of miRNAs in periodontal and peri-implant diseases, while identifying potential miRNAs with the greatest diagnostic ability as an oral fluid biomarker. Human and animal studies were included when evaluating expression of miRNAs between health and different forms/stages of diseases, in which microarray and/or real-time polymerase chain reaction (RT-PCR) was carried out to detect fold changes in gene expression. After full-text analysis, 43 articles were considered for a qualitative assessment, and 16 miRNAs were selected to perform meta-analysis. Based on human studies, results showed an overall upregulation of most of the evaluated miRNAs in periodontitis, with miRNA-142-3p and miRNA-146a being the most conclusive on both microarray and RT-PCR values and potentially serving as diagnostic biomarkers for disease activity. Conversely, miR-155 was the only miRNA revealing a statistically significant difference (SSD) (p < 0.05*) in experimental periodontitis models from RT-PCR values. Scarce scientific evidence is available from peri-implant diseases, however, most explored miRNAs in peri-implantitis were downregulated except for miR-145. Although our results reveale...Continue Reading

References

Jun 1, 1997·Periodontology 2000·R C Page, K S Kornman
Aug 28, 2007·Current Opinion in Immunology·Ian M AdcockKazuhiro Ito
Jan 17, 2008·Nature Reviews. Genetics·Witold FilipowiczNahum Sonenberg
Aug 1, 2008·Nature·Matthias SelbachNikolaus Rajewsky
Sep 4, 2008·Journal of Periodontology·Kenneth S Kornman
Jan 30, 2009·Journal of Cellular and Molecular Medicine·E Sonkoly, A Pivarcsi
Jan 30, 2010·Journal of Dental Research·P-S HungK-W Chang
Jul 24, 2010·British Journal of Pharmacology·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Jul 28, 2011·International Journal of Oral Science·Yu-feng XieXiu-li Zhang
Nov 2, 2011·Journal of Dental Research·R PerriS Offenbacher
Aug 11, 2012·Journal of Dental Research·C Stoecklin-WasmerP N Papapanou
Feb 11, 2014·Archives of Oral Biology·Hai-Tao SunYuxing Bai
Nov 22, 2014·Journal of Periodontology·Lena LarssonWilliam V Giannobile
Dec 17, 2014·Journal of Oral Science·Yorimasa OgataHideki Takai
Jan 30, 2015·Journal of Dental Research·A Z KaleaF D'Aiuto
Aug 11, 2015·Biochimica Et Biophysica Acta·Eléonore M'Baya-MoutoulaLaurent Metzinger
Aug 28, 2015·Journal of Periodontology·Hossein MotedayyenReza Amid
Nov 1, 2015·Journal of Dental Research·X ZhouT G H Diekwisch
Feb 26, 2016·Journal of Clinical Periodontology·Takaaki TomofujiManabu Morita
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ran XuDaxu Li
Oct 30, 2016·Archives of Oral Biology·Rizky Aditiya Irwandi, Anjalee Vacharaksa
Jan 10, 2017·Journal of Dental Research·X LuanT G H Diekwisch
Jul 7, 2017·FEBS Open Bio·Akira SaitoMitsuhiro Ohshima
Apr 24, 2018·Medicina oral, patología oral y cirugía bucal·P Micó-MartínezF-V Pallardó
Jun 10, 2018·Molecular Immunology·Wei ZhouShuang Liang
Aug 7, 2018·International Journal of Oral Science·Xianghong LuanThomas G H Diekwisch
Aug 29, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaolin WuHui Huang
Oct 24, 2018·Oral Diseases·Sérgio Antonucci AmaralLuís Otávio Miranda Cota
Oct 26, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Fanzhen HeYan Xu
Dec 1, 2018·Journal of Clinical Periodontology·Afsar R NaqviSalvador Nares
Jan 9, 2019·Journal of Periodontology·J Bagavad GitaA Gnanamani
Mar 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kohei FujimoriManabu Morita
Mar 20, 2019·Archives of Oral Biology·Toshiki YonedaManabu Morita

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Citations

Dec 2, 2020·Clinical Epigenetics·Krzysztof T JurdzińskiAleksander M Grabiec
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Farah Asa'adLena Larsson
Jan 23, 2021·International Journal of Molecular Sciences·Mikihito Kajiya, Hidemi Kurihara
Aug 8, 2021·International Journal of Environmental Research and Public Health·Kohei FujimoriManabu Morita
Oct 26, 2021·Journal of Oral Science·Adomas RovasSonata Jarmalaite
Jan 1, 2022·Journal of Clinical Periodontology·Lena LarssonRogerio Moraes Castilho

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