Expression of microRNAs in the plasma of patients with acute gouty arthritis and the effects of colchicine and etoricoxib on the differential expression of microRNAs

Archives of Medical Science : AMS
Peng LiuYangang Wang

Abstract

To determine the microRNA (miRNA) expression profiles in the plasma of acute gouty arthritis (AGA) patients and investigate the effects of colchicine and etoricoxib treatment on the differential expression of miRNAs. Exiqon miRCURYLNA microRNA Array was used for miRNA expression profiling in AGA. Two of the 21 differentially expressed miRNAs were confirmed using quantitative real-time polymerase chain reaction (qRT-PCR). A randomized, double-blind, parallel-controlled design was used to divide 160 AGA patients into colchicine and etoricoxib groups. Changes in 2 differentially expressed miRNAs, interleukin-1 (IL-1) β, cyclooxygenase-2 (COX-2) and joint pain scores were detected. Compared with normal subjects and asymptomatic hyperuricemia (HUA) patients, plasma of AGA contained 21 differentially expressed miRNAs. qRT-PCR indicated specific downregulation of miR-223-3p and miR-451a in AGA. There were no statistically significant differences in the baseline characteristics between colchicine and etoricoxib groups. Furthermore, no significant difference in joint pain scores after 5- and 10-day treatment were found between groups (p > 0.05). Comparison of differences between pre- and 5-day post-treatment values confirmed that the up...Continue Reading

Citations

Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Da-Yong HuJun-Yan Liu
Aug 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Huiqin QianYong Song
Mar 3, 2021·International Journal of Rheumatic Diseases·Xiang WangYangang Wang
Jun 1, 2021·Expert Review of Clinical Immunology·Paola GalozziFrancesca Oliviero
Oct 5, 2021·Journal of Clinical Laboratory Analysis·Lizhen ShanXiaolin Li

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GenePix Pro
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